ArticleThe Journal of allergy and clinical immunology2010
Factors predicting inhaled corticosteroid responsiveness in African American patients with asthma.
Article in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.Nature communications · 2019Pooled it
- A randomized clinical trial of a culturally responsive intervention for African American women with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Trial
- Impact of race on asthma treatment failures in the asthma clinical research network.American journal of respiratory and critical care medicine · 2011Trial
- Machine learning models incorporating genotype and ancestry improve severe asthma risk prediction.Scientific reports · 2025Article
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Integrative approach identifies corticosteroid response variant in diverse populations with asthma.The Journal of allergy and clinical immunology · 2019Article
- How does race and ethnicity effect the precision treatment of asthma?Expert review of precision medicine and drug development · 2019Article
- Diversity In Precision Medicine And Pharmacogenetics: Methodological And Conceptual Considerations For Broadening Participation.Pharmacogenomics and personalized medicine · 2019Article
- PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017Article
- Effect of aeroallergen sensitization on asthma control in African American teens with persistent asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Observational
- What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression.Current allergy and asthma reports · 2016Review
- Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects.The Journal of allergy and clinical immunology · 2016Article
- Genetic mapping with multiple levels of phenotypic information reveals determinants of lymphocyte glucocorticoid sensitivity.American journal of human genetics · 2013Article
- Inter-ethnic differences in lymphocyte sensitivity to glucocorticoids reflect variation in transcriptional response.The pharmacogenomics journal · 2013Article
- Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma.The Journal of allergy and clinical immunology · 2012Article
- Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence.The Journal of allergy and clinical immunology · 2011Article
- Advances in pediatric asthma in 2010: addressing the major issues.The Journal of allergy and clinical immunology · 2011Review
- Real-world Drivers Behind Communication, Medication Adherence, and Shared Decision Making In Minority Adults with Asthma.Journal of primary care & community healthArticle
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Authors and funding
20 authors.
Funding
Abstract
backgroundAfrican American patients disproportionately experience uncontrolled asthma. Treatment with an inhaled corticosteroid (ICS) is considered first-line therapy for persistent asthma.
objectiveWe sought to determine the degree to which African American patients respond to ICS medication and whether the level of response is influenced by other factors, including genetic ancestry.
methodsPatients aged 12 to 56 years who received care from a large health system in southeast Michigan and who resided in Detroit were recruited to participate if they had a diagnosis of asthma. Patients were treated with 6 weeks of inhaled beclomethasone dipropionate, and pulmonary function was remeasured after treatment. Ancestry was determined by genotyping ancestry-informative markers. The main outcome measure was ICS responsiveness defined as the change in prebronchodilator FEV(1) over the 6-week course of treatment.
resultsAmong 147 participating African American patients with asthma, average improvement in FEV(1) after 6 weeks of ICS treatment was 11.6%. The mean proportion of African ancestry in this group was 78.4%. The degree of baseline bronchodilator reversibility was the only factor consistently associated with ICS responsiveness, as measured by both an improvement in FEV(1) and patient-reported asthma control (P = .001 and P = .021, respectively). The proportion of African ancestry was not significantly associated with ICS responsiveness.
conclusionsAlthough baseline pulmonary function parameters appear to be associated with the likelihood to respond to ICS treatment, the proportion of genetic African ancestry does not. This study suggests that genetic ancestry might not contribute to differences in ICS controller response among African American patients with asthma.
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