ArticleMolecular cell2010
H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes.
Article in Molecular cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed.
- Differential nucleosome organization in human interphase and metaphase chromosomes.Molecular systems biology · 2026Article
- Mechanisms of gene regulation by SRCAP and H2A.Z.Nature communications · 2026Article
- Differential nucleosome organization in human interphase and metaphase chromosomes.bioRxiv : the preprint server for biology · 2025Article
- Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation.Nature communications · 2023Article
- Mitotic H3K9ac is controlled by phase-specific activity of HDAC2, HDAC3, and SIRT1.Life science alliance · 2022Article
- Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.Scientific reports · 2021Article
- Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency.Stem cell reports · 2020Review
- Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking.Frontiers in pharmacology · 2020Article
- Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.Genes, chromosomes & cancer · 2019Review
- NOMePlot: analysis of DNA methylation and nucleosome occupancy at the single molecule.Scientific reports · 2019Article
- Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription.Cell reports · 2019Article
- Transcription factor activity and nucleosome organization in mitosis.Genome research · 2019Article
- CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning.Genome research · 2019Article
- Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.Molecular cancer research : MCR · 2018Review
- Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns.Genome research · 2018Article
- Article
- ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer.International journal of molecular sciences · 2018Review
- Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.Epigenetics · 2018Article
- Nucleosome Positioning and NDR Structure at RNA Polymerase III Promoters.Scientific reports · 2017Article
- DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.PloS one · 2017Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Profound chromatin changes occur during mitosis to allow for gene silencing and chromosome segregation followed by reactivation of memorized transcription states in daughter cells. Using genome-wide sequencing, we found H2A.Z-containing +1 nucleosomes of active genes shift upstream to occupy TSSs during mitosis, significantly reducing nucleosome-depleted regions. Single-molecule analysis confirmed nucleosome shifting and demonstrated that mitotic shifting is specific to active genes that are silenced during mitosis and, thus, is not seen on promoters, which are silenced by methylation or mitotically expressed genes. Using the GRP78 promoter as a model, we found H3K4 trimethylation is also maintained while other indicators of active chromatin are lost and expression is decreased. These key changes provide a potential mechanism for rapid silencing and reactivation of genes during the cell cycle.
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Registered trials
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