Evidence map›Paper›PMID 20863394›Full record

ArticleLipids in health and disease2010

Effect of HDL composition and particle size on the resistance of HDL to the oxidation.

Nakanishi Shuhei, Sanni Söderlund, Matti Jauhiainen, Marja-Riitta Taskinen

Open access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Observational
  3. Air Pollution: Another Threat to HDL Function.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Article
  6. Apolipoprotein E particle size is increased in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019
    Article
  7. Review
  8. Article
  9. Observational
  10. Development of novel HDL-mimicking α-tocopherol-coated nanoparticles to encapsulate nerve growth factor and evaluation of biodistribution.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2016
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nakanishi ShuheiDivision of Cardiology, Department of Medicine, University of Helsinki, Helsinki, Finland.
Sanni Söderlund
Matti Jauhiainen
Marja-Riitta Taskinen
University of Helsinki · FIInstitute for Molecular Medicine Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the resistance of HDL particles to direct oxidation in respect to the distribution of HDL particles. DESIGN AND

methodsWe studied HDL composition, subclass distribution, and the kinetics of CuSO4-induced oxidation of total HDL and HDL3 in vitro in 36 low-HDL-C subjects and in 41 control subjects with normal HDL-C.

resultsThe resistance of HDL3 to oxidation, as assessed from the propagation rate was significantly higher than that of total HDL. The propagation rate and diene formation during HDL oxidation in vitro was attenuated in HDL derived from low-HDL-C subjects. Propagation rate and maximal diene formation during total HDL oxidation correlated significantly with HDL mean particle size. The propagation rate of total HDL oxidation in vitro displayed a significant positive association with HDL2 particle mass and HDL mean particle size by multiple regression analyses.

conclusionsThese observations highlight that the distribution of HDL subpopulations has important implications for the potential of HDL as an anti-oxidant source.

Indexed as

AdultBiomarkersCardiovascular DiseasesCholesterol, HDLCopper SulfateC-Reactive ProteinFemaleHumansHypolipoproteinemiasInflammationKineticsLipoproteins, HDLLipoproteins, HDL2Lipoproteins, HDL3MaleMiddle AgedBiomarkersCholesterol, HDLCopper SulfateC-Reactive ProteinLipoproteins, HDLLipoproteins, HDL2Lipoproteins, HDL3Oxidants

Identifiers

PMID20863394
PMCPMC2954910
OpenAlexW2171483771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.