Evidence map›Paper›PMID 20863118›Full record

ArticleACS nano2010

Silica-polymer dual layer-encapsulated quantum dots with remarkable stability.

Xiaoge Hu, Xiaohu Gao

Abstract read
In one paragraph

Article in ACS nano, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Passivation and Interlayer Effect of Zr(i-PrO)Nanoscale research letters · 2022
    Article
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  13. Polymersomes containing quantum dots for cellular imaging.International journal of nanomedicine · 2014
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiaoge HuDepartment of Bioengineering, University of Washington, William H Foege Building N530M, Seattle, Washington 98195, United States.
Xiaohu Gao

Funding

Modulation of Qdot nanoparticle toxicity by glutathione in GCL transgenic miceR01ES016189 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAVANAGH, TERRANCE J · 2007 to 2010
$1.9M
Sensitive and multiplexed analysis of cancer biomarkers with QD barcodesR01CA131797 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2008 to 2012
$1.6M
NCI NIH HHS R01 CA131797NCI NIH HHS R01CA131797NIEHS NIH HHS R01 ES016189NIEHS NIH HHS R01ES016189
6 · The paper itself

Abstract

Semiconductor quantum dots (QDs) are important fluorescent probes due to their high brightness, multiplexing capability, and photostability. However, applications in quantitative and in vivo imaging are hampered by their sensitivity to chemical environments and potential toxicity. Here we report a surprising finding that the combination of silica and amphiphilic polymer can stabilize CdSe/ZnS QDs in a broad range of chemical conditions including strong acidic solutions, which is unavailable for any of the current encapsulation technologies (e.g., mercapto compounds, silica, and amphiphilic polymers) used alone. We further demonstrate the use of these ultrastable QDs as internal references in pH sensing applications. We expect this work will open exciting opportunities for in vivo and quantitative applications, and may help solve the toxicity problem of QDs.

Indexed as

Biosensing TechniquesQuantum DotsSemiconductorsCell Line, TumorHumansHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsMicroscopy, Electron, TransmissionMicroscopy, FluorescencePolyethylene GlycolsPolymersProtonsSilicon DioxidePolyethylene GlycolsPolymersProtonsSilicon Dioxide

Identifiers

PMID20863118
PMCPMC2966946

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.