ArticleAnalytical chemistry2010
Integrated post-experiment monoisotopic mass refinement: an integrated approach to accurately assign monoisotopic precursor masses to tandem mass spectrometric data.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- TopPICR: A Companion R Package for Top-Down Proteomics Data Analysis.Journal of proteome research · 2023Article
- A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles.Experimental & molecular medicine · 2018Article
- Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data.Scientific reports · 2017Article
- Multiplexed Post-Experimental Monoisotopic Mass Refinement (mPE-MMR) to Increase Sensitivity and Accuracy in Peptide Identifications from Tandem Mass Spectra of Cofragmentation.Analytical chemistry · 2017Article
- Comprehensive Proteome Profiling of Platelet Identified a Protein Profile Predictive of Responses to An Antiplatelet Agent Sarpogrelate.Molecular & cellular proteomics : MCP · 2016Article
- A protein profile of visceral adipose tissues linked to early pathogenesis of type 2 diabetes mellitus.Molecular & cellular proteomics : MCP · 2014Article
- Accurate identification of deamidated peptides in global proteomics using a quadrupole orbitrap mass spectrometer.Journal of proteome research · 2014Article
- Fully automated multifunctional ultrahigh pressure liquid chromatography system for advanced proteome analyses.Journal of proteome research · 2012Article
- Data analysis strategy for maximizing high-confidence protein identifications in complex proteomes such as human tumor secretomes and human serum.Journal of proteome research · 2011Article
- Detection, evaluation and minimization of nonenzymatic deamidation in proteomic sample preparation.Molecular & cellular proteomics : MCP · 2011Article
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21 authors.
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Abstract
Accurate assignment of monoisotopic precursor masses to tandem mass spectrometric (MS/MS) data is a fundamental and critically important step for successful peptide identifications in mass spectrometry based proteomics. Here we describe an integrated approach that combines three previously reported methods of treating MS/MS data for precursor mass refinement. This combined method, "integrated post-experiment monoisotopic mass refinement" (iPE-MMR), integrates steps (1) generation of refined MS/MS data by DeconMSn; (2) additional refinement of the resultant MS/MS data by a modified version of PE-MMR; and (3) elimination of systematic errors of precursor masses using DtaRefinery. iPE-MMR is the first method that utilizes all MS information from multiple MS scans of a precursor ion including multiple charge states, in an MS scan, to determine precursor mass. With the combination of these methods, iPE-MMR increases sensitivity in peptide identification and provides increased accuracy when applied to complex high-throughput proteomics data.
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