ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging.Brain sciences · 2023Review
- Exploring the Validity of Proposed Transgenic Animal Models of Attention-Deficit Hyperactivity Disorder (ADHD).Molecular neurobiology · 2018Review
- Polymorphisms of STS gene and SULT2A1 gene and neurosteroid levels in Han Chinese boys with attention-deficit/hyperactivity disorder: an exploratory investigation.Scientific reports · 2017Article
- Neurological Manifestations of X-Linked Ichthyosis: Case Report and Review of the Literature.Case reports in genetics · 2017Article
- The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases.Frontiers in pharmacology · 2016Review
- Elucidating X chromosome influences on Attention Deficit Hyperactivity Disorder and executive function.Journal of psychiatric research · 2015Article
- Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison with drugs used in ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder.Molecular autism · 2014Article
- Transgenic mouse models for ADHD.Cell and tissue research · 2013Review
- Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.Psychoneuroendocrinology · 2012Article
- The influence of sex-linked genetic mechanisms on attention and impulsivity.Biological psychology · 2012Review
- Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder.Genes, brain, and behavior · 2011Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
Previous studies in animals and humans have implicated the X-chromosome STS gene in the etiology of attentional difficulties and attention deficit hyperactivity disorder (ADHD). This family based association study has fine mapped a region of the STS gene across intron 1 and 2 previously associated with ADHD, in an extended sample of 450 ADHD probands and their parents. Significant association across this region is demonstrated individually with 7 of the 12 genotyped SNPs, as well as an allele specific haplotype of the 12 SNPs. The over transmitted risk allele of rs12861247 was also associated with reduced STS mRNA expression in normal human post-mortem frontal cortex brain tissue compared to the non-risk allele (P = 0.01). These results are consistent with the hypothesis arising from previous literature demonstrating that boys with deletions of the STS gene, and hence no STS protein are at a significantly increased risk of developing ADHD. Furthermore, this study has established the brain tissue transcript of STS, which except from adipose tissue, differs from that seen in all other tissues investigated. © 2010 Wiley-Liss, Inc.
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