ArticleThe journal of physiological sciences : JPS2010
KB-R7943 inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytes.
Article in The journal of physiological sciences : JPS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Modulation of MgThe journal of physiological sciences : JPS · 2019Article
- Physiological pathway of magnesium influx in rat ventricular myocytes.Biophysical journal · 2014Article
- Mutation of the Mg2+ transporter SLC41A1 results in a nephronophthisis-like phenotype.Journal of the American Society of Nephrology : JASN · 2013Article
- KB-R7943 inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytes.The journal of physiological sciences : JPS · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Na(+)-dependent Mg(2+) efflux activity was studied with the fluorescent Mg(2+) indicator furaptra in the presence of various potential antagonists known to inhibit other transporters and channels. Among the compounds tested, KB-R7943, an inhibitor of Na(+)/Ca(2+) exchange, most potently inhibited the Na(+)/Mg(2+) exchange with half inhibitory concentrations (IC(50)) of 21 μM: (25°C) and 16 μM: (35°C). These IC(50) values were a factor of three to four lower than those of imipramine, a widely used inhibitor of Na(+)/Mg(2+) exchange. Apart from the inhibitory effect on Na(+)/Mg(2+) exchange, relatively high concentrations of KB-R7943 (100 μM: at 25°C and ≥20 μM: at 35°C), in combination with prolonged UV-illumination, caused cell shortening, probably because of the phototoxicity of the compound and the formation of rigor crossbridges. We conclude that KB-R7943 may be a useful tool to study cellular Mg(2+) homeostasis if care is taken to minimize its phototoxicity.
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