ArticlePsychopharmacology2011
Chronic smoking, but not acute nicotine administration, modulates neural correlates of working memory.
Article in Psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Neural bases of pharmacological treatment of nicotine dependence - insights from functional brain imaging: a systematic review.CNS drugs · 2013Pooled it
- Human brain functional network changes associated with enhanced and impaired attentional task performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Electronic Cigarette Use Intentions Mediate the Association between Low Self-Control and Future Use by Internalizing Symptoms.Substance use & misuse · 2022Article
- The negative impact of chronic tobacco smoking on adult neuropsychological function: a cross-sectional study.BMC public health · 2021Article
- Associations Between Smoking Abstinence, Inhibitory Control, and Smoking Behavior: An fMRI Study.Frontiers in psychiatry · 2021Article
- Executive Functions in Tobacco Use Disorder: New Challenges and Opportunities.Frontiers in psychiatry · 2021Article
- A fractionated analysis of hot and cool self-regulation in cigarette smokers from different socioeconomic backgrounds.PloS one · 2019Article
- The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder.Frontiers in psychology · 2017Review
- A reverse factual analysis of the association between smoking and memory decline in China.International journal for equity in health · 2016Article
- Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task.Brain imaging and behavior · 2016Article
- State space modeling of time-varying contemporaneous and lagged relations in connectivity maps.NeuroImage · 2016Article
- Altered human brain anatomy in chronic smokers: a review of magnetic resonance imaging studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Review
- Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans.Neuropharmacology · 2014Review
- Interoception and drug addiction.Neuropharmacology · 2014Review
- Treatment approaches for interoceptive dysfunctions in drug addiction.Frontiers in psychiatry · 2013Review
- Nicotine related brain activity: the influence of smoking history and blood nicotine levels, an exploratory study.Drug and alcohol dependence · 2013Article
- Transcranial direct current stimulation reduces negative affect but not cigarette craving in overnight abstinent smokers.Frontiers in psychiatry · 2013Article
- Functional brain imaging of nicotinic effects on higher cognitive processes.Biochemical pharmacology · 2011Review
- Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior.Biochemical pharmacology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleBeyond the amelioration of deprivation-induced impairments, and in contrast to effects on attentional processes, the cognitive-enhancing properties of nicotine on working memory (WM) operations remain unclear.
objectivesIn an effort to elucidate potential enhancing effects, we explored the impact of transdermal nicotine on neural functioning in minimally deprived smokers and, in addition, assessed differences between smokers and non-smokers using a mixed block/event-related fMRI design that attempted to isolate specific central executive operations (attentional switch events) within general WM function (task blocks).
methodsIn task blocks, participants performed a continuous counting paradigm that required the simultaneous maintenance of, and frequent switching of attentional focus between, two running tallies in WM on some trials. Cigarette smokers (n = 30) were scanned twice, once each with a nicotine and placebo patch, while non-smokers (n = 27) were scanned twice with no patch.
resultsAcross both groups, task blocks were associated with bilateral activation, notably in medial and lateral prefrontal cortex (PFC), anterior insula, and parietal regions, whereas individual attentional switch trials were associated with activation in a similar, but predominantly left-lateralized network. Within the smoker group, although nicotine increased heart rate, altered performance and mood, and reduced tobacco cravings, no acute drug (state-like) effect on brain activity was detected for either the task or switch effects. However, relative to non-smokers, smokers showed greater tonic activation in medial superior frontal cortex, right anterior insula, and bilateral anterior PFC throughout task blocks (trait-like effect).
conclusionsThese data suggest smokers require recruitment of additional WM and supervisory control operations during task performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.