ArticlePLoS genetics2010
The metabolic enzyme ManA reveals a link between cell wall integrity and chromosome morphology.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Universal receptive system as a novel regulator of transcriptomic activity of Staphylococcus aureus.Microbial cell factories · 2025Article
- Investigating the role of theFEMS microbes · 2025Article
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- Metabolic Control of Cell Elongation and Cell Division inFrontiers in microbiology · 2021Review
- Disruption of the MreB Elongasome Is Overcome by Mutations in the Tricarboxylic Acid Cycle.Frontiers in microbiology · 2021Article
- Sugar-Phosphate Metabolism Regulates Stationary-Phase Entry and Stalk Elongation in Caulobacter crescentus.Journal of bacteriology · 2020Article
- Phosphosugar Stress in Bacillus subtilis: Intracellular Accumulation of Mannose 6-Phosphate Derepressed theJournal of bacteriology · 2019Article
- Article
- Tunicamycin Mediated Inhibition of Wall Teichoic Acid AffectsFrontiers in microbiology · 2018Article
- Thinking big: the tunability of bacterial cell size.FEMS microbiology reviews · 2017Review
- Crosstalk between the tricarboxylic acid cycle and peptidoglycan synthesis in Caulobacter crescentus through the homeostatic control of α-ketoglutarate.PLoS genetics · 2017Article
- Metabolism Shapes the Cell.Journal of bacteriology · 2017Review
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- Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division.Protein & cell · 2014Article
- Wall teichoic acids of gram-positive bacteria.Annual review of microbiology · 2013Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synchronizing cell growth, division and DNA replication is an essential property of all living cells. Accurate coordination of these cellular events is especially crucial for bacteria, which can grow rapidly and undergo multifork replication. Here we show that the metabolic protein ManA, which is a component of mannose phosphotransferase system, participates in cell wall construction of the rod shaped bacterium Bacillus subtilis. When growing rapidly, cells lacking ManA exhibit aberrant cell wall architecture, polyploidy and abnormal chromosome morphologies. We demonstrate that these cellular defects are derived from the role played by ManA in cell wall formation. Furthermore, we show that ManA is required for maintaining the proper carbohydrate composition of the cell wall, particularly of teichoic acid constituents. This perturbed cell wall synthesis causes asynchrony between cell wall elongation, division and nucleoid segregation.
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