ArticlePLoS pathogens2010
Dynamics of the multiplicity of cellular infection in a plant virus.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 80 citations in OpenAlex.
- Article
- A dominant role of cell death in limiting Chandipura virus propagation at cell-saturating high multiplicity of infection.bioRxiv : the preprint server for biology · 2025Article
- Intracellular bottlenecking permits no more than three tomato yellow leaf curl virus genomes to initiate replication in a single cell.PLoS pathogens · 2023Article
- Cheating leads to the evolution of multipartite viruses.PLoS biology · 2023Article
- Article
- Cooperative Virus-Virus Interactions: An Evolutionary Perspective.Biodesign research · 2022Review
- The evolution of cheating in viruses.Nature communications · 2021Review
- Plant death caused by inefficient induction of antiviral R-gene-mediated resistance may function as a suicidal population resistance mechanism.Communications biology · 2021Article
- Effects of historical co-infection on host shift abilities of exploitative and competitive viruses.Evolution; international journal of organic evolution · 2021Article
- Comparison of two Turnip mosaic virus P1 proteins in their ability to co-localize with the Arabidopsis thaliana G3BP-2 protein.Virus genes · 2021Article
- Analyzing the G3BP-like gene family of Arabidopsis thaliana in early turnip mosaic virus infection.Scientific reports · 2021Article
- Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response.PLoS pathogens · 2020Article
- Competition between social cheater viruses is driven by mechanistically different cheating strategies.Science advances · 2020Article
- Modeling multipartite virus evolution: the genome formula facilitates rapid adaptation to heterogeneous environmentsVirus evolution · 2020Article
- Impact of genetic drift, selection and accumulation level on virus adaptation to its host plants.Molecular plant pathology · 2018Article
- Beneficial coinfection can promote within-host viral diversity.Virus evolution · 2018Article
- Nonlinear trade-offs allow the cooperation game to evolve from Prisoner's Dilemma to Snowdrift.Proceedings. Biological sciences · 2017Article
- GB3.0: a platform for plant bio-design that connects functional DNA elements with associated biological data.Nucleic acids research · 2017Article
- Multipartite viruses: adaptive trick or evolutionary treat?NPJ systems biology and applications · 2017Review
- HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell.PLoS pathogens · 2016Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recombination, complementation and competition profoundly influence virus evolution and epidemiology. Since viruses are intracellular parasites, the basic parameter determining the potential for such interactions is the multiplicity of cellular infection (cellular MOI), i.e. the number of viral genome units that effectively infect a cell. The cellular MOI values that prevail in host organisms have rarely been investigated, and whether they remain constant or change widely during host invasion is totally unknown. Here, we fill this experimental gap by presenting the first detailed analysis of the dynamics of the cellular MOI during colonization of a host plant by a virus. Our results reveal ample variations between different leaf levels during the course of infection, with values starting close to 2 and increasing up to 13 before decreasing to initial levels in the latest infection stages. By revealing wide dynamic changes throughout a single infection, we here illustrate the existence of complex scenarios where the opportunity for recombination, complementation and competition among viral genomes changes greatly at different infection phases and at different locations within a multi-cellular host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.