ArticlePloS one2010
Stabilisation of β-catenin downstream of T cell receptor signalling.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state.Immunity · 2024Article
- IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells.Nature communications · 2023Article
- LiCl-induced immunomodulatory periodontal regeneration via the activation of the Wnt/β-catenin signaling pathway.Journal of periodontal research · 2022Article
- A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability.EMBO molecular medicine · 2022Article
- Article
- Hippo Signal Transduction Mechanisms in T Cell Immunity.Immune network · 2020Review
- Transcriptomic features of tumour-infiltrating CD4Scientific reports · 2020Observational
- Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?Frontiers in cell and developmental biology · 2020Review
- Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice.Nutrients · 2019Article
- Gimap5-dependent inactivation of GSK3β is required for CD4Nature communications · 2018Article
- The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells.Biology open · 2018Article
- Colorectal cancer cells suppress CD4+ T cells immunity through canonical Wnt signaling.Oncotarget · 2017Article
- Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.Oncogene · 2016Article
- Angiotensin II increases fibronectin and collagen I through the β-catenin-dependent signaling in mouse collecting duct cells.American journal of physiology. Renal physiology · 2015Article
- TCR Signaling in T Cell Memory.Frontiers in immunology · 2015Review
- EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells.Oncogene · 2014Article
- Sex-dependent genetic effects on immune responses to a parasitic nematode.BMC genomics · 2014Article
- Down-regulation of PLCγ2-β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer.The Journal of experimental medicine · 2013Article
- Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres.Translational psychiatry · 2013Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe role of TCF/β-catenin signalling in T cell development is well established, but important roles in mature T cells have only recently come to light. METHODOLOGY/PRINCIPAL
findingsHere we have investigated the signalling pathways that are involved in the regulation of β-catenin in primary human T cells. We demonstrate that β-catenin expression is upregulated rapidly after T cell receptor (TCR) stimulation and that this involves protein stabilisation rather than an increase in mRNA levels. Similar to events in Wnt signalling, the increase in β-catenin coincides with an inhibition of GSK3, the kinase that is required for β-catenin degradation. β-catenin stabilisation in T cells can also be induced by the activation of PKC with phorbol esters and is blocked by inhibitors of phosphatidylinositol 3-kinase (PI3K) and phospholipase C (PKC). Upon TCR signalling, β-catenin accumulates in the nucleus and, parallel to this, the ratio of TCF1 isoforms is shifted in favour of the longer β-catenin binding isoforms. However, phosphorylated β-catenin, which is believed to be inactive, can also be detected and the expression of Wnt target genes Axin2 and dickkopf is down regulated. CONCLUSIONS/SIGNIFICANCE: These data show that in mature human T cells, TCR signalling via PI3K and PKC can result in the stabilisation of β-catenin, allowing β-catenin to migrate to the nucleus. They further highlight important differences between β-catenin activities in TCR and Wnt signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.