Evidence map›Paper›PMID 20861925›Full record

ReviewJournal of stem cells2010

Immunological control of adult neural stem cells.

Oscar Gonzalez-Perez, Alfredo Quiñones-Hinojosa, Jose Manuel Garcia-Verdugo

Abstract readReview
In one paragraph

Review in Journal of stem cells, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Neuroimmunomodulation in unipolar depression: a focus on chronobiology and chronotherapeutics.Journal of neural transmission (Vienna, Austria : 1996) · 2012
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Neural stem cells in the adult human brain.Biological and biomedical reports · 2012
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Oscar Gonzalez-PerezNeuroscience Laboratory, Psychology School, University of Colima, Colima, Mexico 28040. osglez@gmail.com
Alfredo Quiñones-Hinojosa
Jose Manuel Garcia-Verdugo

Funding

Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 StimulationR01NS070024 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QUINONES-HINOJOSA, ALFREDO · 2010 to 2014
$2.4M
Migration of Human Neural Stem Cells In Vitro and In VivoK08NS055851 · NINDS · JOHNS HOPKINS UNIVERSITY · PI QUINONES-HINOJOSA, ALFREDO · 2006 to 2010
$880k
Howard Hughes Medical InstituteNINDS NIH HHS K08 NS055851NINDS NIH HHS R01 NS070024
6 · The paper itself

Abstract

Adult neurogenesis occurs only in discrete regions of adult central nervous system: the subventricular zone and the subgranular zone. These areas are populated by adult neural stem cells (aNSC) that are regulated by a number of molecules and signaling pathways, which control their cell fate choices, survival and proliferation rates. For a long time, it was believed that the immune system did not exert any control on neural proliferative niches. However, it has been observed that many pathological and inflammatory conditions significantly affect NSC niches. Even more, increasing evidence indicates that chemokines and cytokines play an important role in regulating proliferation, cell fate choices, migration and survival of NSCs under physiological conditions. Hence, the immune system is emerging is an important regulator of neurogenic niches in the adult brain, which may have clinical relevance in several brain diseases.

Indexed as

AdultAdult Stem CellsCell DifferentiationHumansNeural Stem CellsNeurogenesisNeuroimmunomodulation

Identifiers

PMID20861925
PMCPMC2946325

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.