ArticleMucosal immunology2011
Mast cell/IL-4 control of Francisella tularensis replication and host cell death is associated with increased ATP production and phagosomal acidification.
Article in Mucosal immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- The immune response toFrontiers in microbiology · 2025Review
- Microbial co-infection alters macrophage polarization, phagosomal escape, and microbial killing.Innate immunity · 2018Article
- Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice.Allergy · 2018Article
- Mast Cells Respond toFrontiers in immunology · 2018Article
- Roles and relevance of mast cells in infection and vaccination.Journal of biomedical research · 2016Review
- Chlamydia pneumoniae promotes dysfunction of pancreatic beta cells.Cellular immunology · 2015Article
- M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae.PloS one · 2015Article
- Mast cell function: a new vision of an old cell.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Review
- Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence.Cell host & microbe · 2013Article
- Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Mechanisms of Francisella tularensis intracellular pathogenesis.Cold Spring Harbor perspectives in medicine · 2013Review
- Mast cells: multitalented facilitators of protection against bacterial pathogens.Expert review of clinical immunology · 2013Review
- Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.Autophagy · 2012Article
- Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Comparison of bone marrow-derived and mucosal mast cells in controlling intramacrophage Francisella tularensis replication.Experimental biology and medicine (Maywood, N.J.) · 2012Article
- Non-FcεR bearing mast cells secrete sufficient interleukin-4 to control Francisella tularensis replication within macrophages.Cytokine · 2011Article
- Phagocytic receptors dictate phagosomal escape and intracellular proliferation of Francisella tularensis.Infection and immunity · 2011Article
- Immunity to Francisella.Frontiers in microbiology · 2011Article
- The francisella intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferation.Frontiers in microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Mast cells are now recognized as effective modulators of innate immunity. We recently reported that mast cells and secreted interleukin-4 (IL-4) effectively control intramacrophage replication of Francisella tularensis Live Vaccine Strain (LVS), and that mice deficient in mast cells or IL-4 receptor (IL-4R(-/-)) exhibit greater susceptibility to pulmonary challenge. In this study, we further evaluated the mechanism(s) by which mast cells/IL-4 control intramacrophage bacterial replication and host cell death, and found that IL-4R(-/-) mice exhibited significantly greater induction of active caspase-3 within lung macrophages than wild-type animals following intranasal challenge with either LVS or the human virulent type A strain SCHU S4. Treatment of LVS-infected bone-marrow-derived macrophages with a pancaspase inhibitor (zVAD) did not alter bacterial replication, but minimized active caspase-3 and other markers (Annexin V and propidium iodide) of cell death, whereas treatment with both rIL-4 and zVAD resulted in concomitant reduction of both parameters, suggesting that inhibition of bacterial replication by IL-4 was independent of caspase activation. Interestingly, IL-4-treated infected macrophages exhibited significantly increased ATP production and phagolysosomal acidification, as well as enhanced mannose receptor upregulation and increased internalization with acidification, which correlated with observations in mast cell-macrophage co-cultures, with resultant decreases in F. tularensis replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.