ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Glutamatergic model psychoses: prediction error, learning, and inference.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sense of agency and its disturbances: A systematic review targeting the intentional binding effect in neuropsychiatric disorders.Psychiatry and clinical neurosciences · 2024Pooled it
- The effects of intravenous tramadol vs. intravenous ketamine in the prevention of shivering during spinal anesthesia: A meta-analysis of randomized controlled trials.Frontiers in medicine · 2022Pooled it
- Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.Psychopharmacology · 2024Trial
- Trial
- Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans.Journal of psychiatry & neuroscience : JPN · 2017Trial
- Time, action and psychosis: using subjective time to investigate the effects of ketamine on sense of agency.Neuropsychologia · 2013Trial
- Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Psychedelic-Related Psychosis: From Model Psychosis to Psychotherapy.Current topics in behavioral neurosciences · 2026Review
- Phenomenology of Psychedelic Experiences and Psychedelic-Associated Distressing Effects: Quantifying Subjective Experiences.Current topics in behavioral neurosciences · 2026Review
- Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects.Current topics in behavioral neurosciences · 2026Review
- Molecular Mechanisms Underlying Chronic High-Dose Ketamine-Induced Apoptosis in the Hippocampus: A Narrative Review.Neurochemical research · 2025Review
- Large-scale maps of altered cortical dynamics in early-stage psychosis are related to GABAergic and glutamatergic neurotransmission.Science advances · 2025Article
- N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.Brain : a journal of neurology · 2025Article
- That men should put an enemy in their mouths to steal away their brains: Reconsidering the origins of model psychosis.History of the human sciences · 2025Article
- A Computational Account of the Development and Evolution of Psychotic Symptoms.Biological psychiatry · 2025Review
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Article
- Synthetic surprise as the foundation of the psychedelic experience.Neuroscience and biobehavioral reviews · 2024Review
- Noradrenergic gene variation shaping vulnerability and resilience by affecting mental health-related characteristics: A systematic review.Neuroscience applied · 2024Article
- Resolving the Delusion Paradox.Schizophrenia bulletin · 2023Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Modulating glutamatergic neurotransmission induces alterations in conscious experience that mimic the symptoms of early psychotic illness. We review studies that use intravenous administration of ketamine, focusing on interindividual variability in the profundity of the ketamine experience. We will consider this individual variability within a hypothetical model of brain and cognitive function centered upon learning and inference. Within this model, the brains, neural systems, and even single neurons specify expectations about their inputs and responding to violations of those expectations with new learning that renders future inputs more predictable. We argue that ketamine temporarily deranges this ability by perturbing both the ways in which prior expectations are specified and the ways in which expectancy violations are signaled. We suggest that the former effect is predominantly mediated by NMDA blockade and the latter by augmented and inappropriate feedforward glutamatergic signaling. We suggest that the observed interindividual variability emerges from individual differences in neural circuits that normally underpin the learning and inference processes described. The exact source for that variability is uncertain, although it is likely to arise not only from genetic variation but also from subjects' previous experiences and prior learning. Furthermore, we argue that chronic, unlike acute, NMDA blockade alters the specification of expectancies more profoundly and permanently. Scrutinizing individual differences in the effects of acute and chronic ketamine administration in the context of the Bayesian brain model may generate new insights about the symptoms of psychosis; their underlying cognitive processes and neurocircuitry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.