ArticleInvestigative ophthalmology & visual science2011
Tight junction-associated signaling pathways modulate cell proliferation in uveal melanoma.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor-Positive Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Trial
- TheBiology · 2025Article
- Article
- Identification and verification of YBX3 and its regulatory gene HEIH as an oncogenic system: A multidimensional analysis in colon cancer.Frontiers in immunology · 2022Article
- Chimeric Claudins: A New Tool to Study Tight Junction Structure and Function.International journal of molecular sciences · 2021Article
- Review
- Tight Junctions in Cell Proliferation.International journal of molecular sciences · 2019Review
- Low Expression of Occludin in the Melanoma Patient.Iranian journal of pathology · 2019Article
- BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability.Mucosal immunology · 2018Article
- Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway.International journal of molecular medicine · 2018Article
- Cystic fibrosis transmembrane conductance regulator-emerging regulator of cancer.Cellular and molecular life sciences : CMLS · 2018Review
- Blood Vessel Epicardial Substance (BVES) in junctional signaling and cancer.Tissue barriers · 2018Review
- Correlation of histopathologic characteristics to protein expression and function in malignant melanoma.PloS one · 2017Article
- Cold Shock Proteins Mediate GN with Mesangioproliferation.Journal of the American Society of Nephrology : JASN · 2016Article
- BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation.Stem cells (Dayton, Ohio) · 2016Article
- The Popeye domain containing protein family--A novel class of cAMP effectors with important functions in multiple tissues.Progress in biophysics and molecular biology · 2016Review
- Membrane-initiated estradiol signaling of epithelial-mesenchymal transition-associated mechanisms through regulation of tight junctions in human breast cancer cells.Hormones & cancer · 2014Article
- Tight junction proteins: from barrier to tumorigenesis.Cancer letters · 2013Review
- Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key.Frontiers in genetics · 2013Article
- Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer.World journal of gastroenterology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the role of tight junction (TJ)-associated signaling pathways in the proliferation of uveal melanoma.
methodsHuman uveal melanoma cell lines overexpressing the TJ molecule blood vessel epicardial substance (Bves) were generated. The effects of Bves overexpression on TJ protein expression, cell proliferation, and cell cycle distribution were quantified. In addition, localization and transcription activity of the TJ-associated protein ZO-1-associated nucleic acid binding protein (ZONAB) were evaluated using immunofluorescence and bioluminescence reporter assays to study the involvement of Bves signaling in cell proliferation-associated pathways.
resultsBves overexpression in uveal melanoma cell lines resulted in increased expression of the TJ proteins occludin and ZO-1, reduced cell proliferation, and increased sequestration of ZONAB at TJs and reduced ZONAB transcriptional activity.
conclusionsTJ proteins are present in uveal melanoma, and TJ-associated signaling pathways modulate cell signaling pathways relevant to proliferation in uveal melanoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.