ArticleProceedings of the National Academy of Sciences of the United States of America2010
Epigenetic modifications on X chromosomes in marsupial and monotreme mammals and implications for evolution of dosage compensation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 86 citations in OpenAlex.
- Review
- DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage.Nature communications · 2026Article
- Xist RNA dependent and independent mechanisms regulate dynamic X chromosome inactivation in B lymphocytes.Cell reports · 2026Article
- Cytogenetic Analysis of Histone Gene and DNA Methylation in Amazonian Turtles (Chelonia: Podocnemididae).ACS omega · 2025Article
- X chromosome inactivation in mammals: general principles and species-specific considerations.EMBO reports · 2025Review
- Article
- Imprinted X chromosome inactivation in marsupials: The paternal X arrives at the egg with a silent DNA methylation profile.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Identification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation.Genome biology · 2024Article
- H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos.Chromosoma · 2023Article
- Cell-type-specific epigenetic effects of early life stress on the brain.Translational psychiatry · 2022Review
- Meiotic behavior, transmission and active genes of B chromosomes in the cichlid Astatotilapia latifasciata: new clues about nature, evolution and maintenance of accessory elements.Molecular genetics and genomics : MGG · 2022Article
- The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.Cold Spring Harbor perspectives in biology · 2022Review
- Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.Nature communications · 2022Article
- Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming.Stem cell reports · 2022Article
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Epigenetics drive the evolution of sex chromosomes in animals and plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Koala methylomes reveal divergent and conserved DNA methylation signatures of X chromosome regulation.Proceedings. Biological sciences · 2021Article
- Meiotic analyses show adaptations to maintenance of fertility in X1Y1X2Y2X3Y3X4Y4X5Y5 system of amazon frog Leptodactylus pentadactylus (Laurenti, 1768).Scientific reports · 2020Article
- Epigenetic DNA Modifications Are Correlated With B Chromosomes and Sex in the CichlidFrontiers in genetics · 2019Article
- The methylation and telomere landscape in two families of marsupials with different rates of chromosome evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
X chromosome dosage compensation in female eutherian mammals is regulated by the noncoding Xist RNA and is associated with the differential acquisition of active and repressive histone modifications, resulting in repression of most genes on one of the two X chromosome homologs. Marsupial mammals exhibit dosage compensation; however, they lack Xist, and the mechanisms conferring epigenetic control of X chromosome dosage compensation remain elusive. Oviparous mammals, the monotremes, have multiple X chromosomes, and it is not clear whether they undergo dosage compensation and whether there is epigenetic dimorphism between homologous pairs in female monotremes. Here, using antibodies against DNA methylation, eight different histone modifications, and HP1, we conduct immunofluorescence on somatic cells of the female Australian marsupial possum Trichosurus vulpecula, the female platypus Ornithorhynchus anatinus, and control mouse cells. The two marsupial X's were different for all epigenetic features tested. In particular, unlike in the mouse, both repressive modifications, H3K9me3 and H4K20Me3, are enriched on one of the X chromosomes, and this is associated with the presence of HP1 and hypomethylation of DNA. Using sequential labeling, we determine that this DNA hypomethylated X correlates with histone marks of inactivity. These results suggest that female marsupials use a repressive histone-mediated inactivation mechanism and that this may represent an ancestral dosage compensation process that differs from eutherians that require Xist transcription and DNA methylation. In comparison to the marsupial, the monotreme exhibited no epigenetic differences between homologous X chromosomes, suggesting the absence of a dosage compensation process comparable to that in therians.
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