ArticleJournal of neurophysiology2010
Spatiotemporal dynamics of rhythmic spinal interneurons measured with two-photon calcium imaging and coherence analysis.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Network Bursts in 3D Neuron Clusters Cultured on Microcontact-Printed Substrates.Micromachines · 2023Article
- Lumbar multiunit activity power spectrum during air stepping in the spinal cat: evidence for a flexor-dominated rostrocaudally distributed locomotor center.Journal of neurophysiology · 2023Article
- Article
- Single-cell and ensemble activity of lumbar intermediate and ventral horn interneurons in the spinal air-stepping cat.Journal of neurophysiology · 2022Article
- Optogenetic Activation of V1 Interneurons Reveals the Multimodality of Spinal Locomotor Networks in the Neonatal Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- InterpretingNeurophotonics · 2020Review
- Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord.Nature communications · 2019Article
- Data-driven analysis of motor activity implicates 5-HT2A neurons in backward locomotion of larval Drosophila.Scientific reports · 2018Article
- Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury.The Journal of physiology · 2018Article
- Delineating the Diversity of Spinal Interneurons in Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Neuronal Population Activity in Spinal Motor Circuits: Greater Than the Sum of Its Parts.Frontiers in neural circuits · 2017Review
- Imaging fictive locomotor patterns in larval Drosophila.Journal of neurophysiology · 2015Article
- Imaging spinal neuron ensembles active during locomotion with genetically encoded calcium indicators.Annals of the New York Academy of Sciences · 2013Review
- TTX-resistant NMDA receptor-mediated membrane potential oscillations in neonatal mouse Hb9 interneurons.PloS one · 2012Article
- Population spatiotemporal dynamics of spinal intermediate zone interneurons during air-stepping in adult spinal cats.Journal of neurophysiology · 2011Article
- Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord.Nature communications · 2011Article
- Functional organization of locomotor interneurons in the ventral lumbar spinal cord of the newborn rat.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In rhythmic neural circuits, a neuron often fires action potentials with a constant phase to the rhythm, a timing relationship that can be functionally significant. To characterize these phase preferences in a large-scale, cell type-specific manner, we adapted multitaper coherence analysis for two-photon calcium imaging. Analysis of simulated data showed that coherence is a simple and robust measure of rhythmicity for calcium imaging data. When applied to the neonatal mouse hindlimb spinal locomotor network, the phase relationships between peak activity of >1,000 ventral spinal interneurons and motor output were characterized. Most interneurons showed rhythmic activity that was coherent and in phase with the ipsilateral motor output during fictive locomotion. The phase distributions of two genetically identified classes of interneurons were distinct from the ensemble population and from each other. There was no obvious spatial clustering of interneurons with similar phase preferences. Together, these results suggest that cell type, not neighboring neuron activity, is a better indicator of an interneuron's response during fictive locomotion. The ability to measure the phase preferences of many neurons with cell type and spatial information should be widely applicable for studying other rhythmic neural circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.