ArticleClinical and vaccine immunology : CVI2010
Characterization of pneumonia due to Streptococcus equi subsp. zooepidemicus in dogs.
Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Streptococcal infections in cats: ABCD guidelines on prevention and management.Journal of feline medicine and surgery · 2015Guideline
- Effectiveness of a screening protocol employed at a UK rescue centre to prevent introduction of strangles.Equine veterinary journal · 2026Article
- Recognition and Diagnosis of Underlying Disease Processes in Bacterial Pneumonia.Animals : an open access journal from MDPI · 2024Review
- Antibacterial activity of plant extracts againstHeliyon · 2024Article
- Species-level characterization of the core microbiome in healthy dogs using full-length 16S rRNA gene sequencing.Frontiers in veterinary science · 2024Article
- Pathogenic Characteristics of an Infection with Canine Influenza Virus andTransboundary and emerging diseases · 2024Article
- Canine Infectious Respiratory Disease.The Veterinary clinics of North America. Small animal practice · 2020Review
- Respiratory Dysbiosis in Canine Bacterial Pneumonia: Standard Culture vs. Microbiome Sequencing.Frontiers in veterinary science · 2019Article
- Novel Parvovirus Related to Primate Bufaviruses in Dogs.Emerging infectious diseases · 2018Article
- Molecular surveillance of traditional and emerging pathogens associated with canine infectious respiratory disease.Veterinary microbiology · 2016Article
- Prevalence of canine infectious respiratory pathogens in asymptomatic dogs presented at US animal shelters.The Journal of small animal practice · 2015Article
- Clones of Streptococcus zooepidemicus from outbreaks of hemorrhagic canine pneumonia and associated immune responses.Clinical and vaccine immunology : CVI · 2014Article
- Full-genome analysis of a canine pneumovirus causing acute respiratory disease in dogs, Italy.PloS one · 2014Article
- Haemorrhagic pneumonia in sled dogs caused by Streptococcus equi subsp. zooepidemicus - one fatality and two full recoveries: a case report.Acta veterinaria Scandinavica · 2013Article
- Canine infectious respiratory disease: tackling the unknown unknowns.Veterinary journal (London, England : 1997) · 2012Article
- A review of the pathology and treatment of canine respiratory infections.Veterinary medicine (Auckland, N.Z.) · 2012Review
- Presumptive meningoencephalitis secondary to extension of otitis media/interna caused by Streptococcus equi subspecies zooepidemicus in a cat.Journal of feline medicine and surgery · 2011Article
- The respiratory microbiota and its impact on health and disease in dogs and cats: A One Health perspective.Journal of veterinary internal medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Streptococcus equi subsp. zooepidemicus has been linked to cases of acute fatal pneumonia in dogs in several countries. Outbreaks can occur in kenneled dog populations and result in significant levels of morbidity and mortality. This highly contagious disease is characterized by the sudden onset of clinical signs, including pyrexia, dyspnea, and hemorrhagic nasal discharge. The pathogenesis of S. equi subsp. zooepidemicus infection in dogs is poorly understood. This study systematically characterized the histopathological changes in the lungs of 39 dogs from a large rehoming shelter in London, United Kingdom; the dogs were infected with S. equi subsp. zooepidemicus. An objective scoring system demonstrated that S. equi subsp. zooepidemicus caused pneumonia in 26/39 (66.7%) dogs, and most of these dogs (17/26 [65.4%]) were classified as severe fibrino-suppurative, necrotizing, and hemorrhagic. Three recently described superantigen genes (szeF, szeN, and szeP) were detected by PCR in 17/47 (36.2%) of the S. equi subsp. zooepidemicus isolates; however, there was no association between the presence of these genes and the histopathological score. The lungs of S. equi subsp. zooepidemicus-infected dogs with severe respiratory signs and lung pathology did however have significantly higher mRNA levels of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 8 (IL-8) than in uninfected controls, suggesting a role for an exuberant host immune response in the pathogenesis of this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.