ArticleThe Journal of clinical endocrinology and metabolism2010
Identifying dysglycemic states in older adults: implications of the emerging use of hemoglobin A1c.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02978807 (Establishing the Prevalance and Accuracy of Different Diagnostic Techniques for Gestational Diabetes in the Resource-constrained Setting of Eldoret, Kenya), which is not on this map. Cited by 44 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishing the Prevalance and Accuracy of Different Diagnostic Techniques for Gestational Diabetes in the Resource-constrained Setting of Eldoret, Kenya
Who cites it
44 citing papers in PubMed.
- Racial differences in measures of glycemia in the Vitamin D and Type 2 Diabetes (D2d) Study: a secondary analysis of a randomized trial.BMJ open diabetes research & care · 2024Trial
- Protocol for the CHORD project (community health outreach to reduce diabetes): a cluster-randomized community health worker trial to prevent diabetes.BMC public health · 2018Trial
- The changing relationship between HbA1c and FPG according to different FPG ranges.Journal of endocrinological investigation · 2016Trial
- Screening for Turner Syndrome-Associated Hyperglycemia: Evaluating Hemoglobin A1c and Fasting Blood Glucose.Hormone research in paediatrics · 2024Article
- Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c.Nature medicine · 2023Article
- The Prognostic Significance of Early Glycemic Profile in Acute Ischemic Stroke Depends on Stroke Subtype.Journal of clinical medicine · 2023Article
- Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage.Scientific reports · 2021Article
- Concordance between fasting plasma glucose and HbABMJ open · 2021Article
- Association of Protein Z with Prediabetes and Type 2 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Prevalence of Undiagnosed Diabetes in 2004 and 2012: Evidence From the English Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Diabetes in ageing: pathways for developing the evidence base for clinical guidance.The lancet. Diabetes & endocrinology · 2020Review
- Pitfalls of HbA1c in the Diagnosis of Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
- Review of methods for detecting glycemic disorders.Diabetes research and clinical practice · 2020Review
- The COVID-19 Pandemic during the Time of the Diabetes Pandemic: Likely Fraternal Twins?Pathogens (Basel, Switzerland) · 2020Review
- Association of prestroke glycemic status with stroke mortality.BMJ open diabetes research & care · 2020Article
- The Oral Glucose Tolerance Test: 100 Years Later.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- The association between fasting plasma glucose and glycated hemoglobin in the prediabetes range and future development of hypertension.Cardiovascular diabetology · 2019Article
- Circulating miRNAs as Predictive Biomarkers of Type 2 Diabetes Mellitus Development in Coronary Heart Disease Patients from the CORDIOPREV Study.Molecular therapy. Nucleic acids · 2018Article
- Assessment of disturbed glucose metabolism and surrogate measures of insulin sensitivity in obese children and adolescents.Nutrition & diabetes · 2017Article
- Diabetic by HbA1c, Normal by OGTT: A Frequent Finding in the Mexico City Diabetes Study.Journal of the Endocrine Society · 2017Article
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11 authors.
Funding
Abstract
contextHemoglobin A1c (A1c) was recently added to the diagnostic criteria for diabetes and prediabetes.
objectiveOur objective was to examine performance of A1c in comparison with fasting plasma glucose (FPG) in diagnosing dysglycemia in older adults. DESIGN AND
settingWe conducted a cross-sectional analysis of data from the Health, Aging, and Body Composition study at yr 4 (2000-2001) when FPG and standardized A1c measurements were available.
participantsOf 3075 persons (aged 70-79 yr, 48% men, 42% Black) at study entry, 1865 participants without known diabetes who had appropriate measures were included.
main outcome measuresSensitivity and specificity of A1c-based diagnoses were compared with those based on FPG and the proportion of participants identified with dysglycemia by each measure.
resultsOf all participants, 2.7 and 3.1% had undiagnosed diabetes by FPG≥126 mg/dl and A1c≥6.5%, respectively. Among the remaining participants, 21.1% had prediabetes by impaired fasting glucose (≥100 mg/dl) and 22.2% by A1c≥5.7%. Roughly one third of individuals with diabetes and prediabetes were identified by either FPG or A1c alone and by both tests simultaneously. Sensitivities and specificities of A1c compared with FPG were 56.9 and 98.4% for diabetes and 47.0 and 84.5% for prediabetes, respectively. Blacks and women were more likely to be identified with dysglycemia by A1c than FPG.
conclusionsIn this older population, we found considerable discordance between FPG- and A1c-based diagnosis of diabetes and prediabetes, with differences accentuated by race and gender. Broad implementation of A1c to diagnose dysglycemic states may substantially alter the epidemiology of these conditions in older Americans.
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