ArticleBritish journal of anaesthesia2010
Incidence and risk factors for fatal pulmonary embolism after major trauma: a nested cohort study.
Article in British journal of anaesthesia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07506473 (Intermediate Versus Standard Dose Enoxaparin to Prevent Venous Thromboembolism in Severe Trauma Patients), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intermediate Versus Standard Dose Enoxaparin to Prevent Venous Thromboembolism in Severe Trauma Patients: a Multicenter Double Blind Randomised Controlled Trial
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Computed tomography pulmonary angiography (CTPA) for the detection of pulmonary embolism (PE) among trauma patients: a systematic review and meta-analysis.Emergency radiology · 2024Pooled it
- Venous thromboembolic events in critically ill traumatic brain injury patients.Intensive care medicine · 2017Trial
- Incidence and Risk Factors of Deep Vein Thrombosis in Patients With Pelvic and Acetabular Fractures.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisTrial
- Violent death and Post-traumatic pulmonary embolism during hospital admission.Forensic science, medicine, and pathology · 2026Article
- Venous thromboembolism chemoprophylaxis after severe polytrauma: timing and type of prophylaxis matter.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Review
- Venous Thrombus Embolism in Polytrauma: Special Attention to Patients with Traumatic Brain Injury.Journal of clinical medicine · 2023Article
- Incremental cost of venous thromboembolism in trauma patients with contraindications to prophylactic anticoagulation: a prospective economic study.Journal of thrombosis and thrombolysis · 2022Article
- Article
- Clinical Characteristics and Risk Factors for Early versus Late Pulmonary Embolism in Trauma Patients: A Retrospective, Observational Study.International journal of general medicine · 2022Article
- Venous Thromboembolism in Trauma: The Role of Anticoagulation and Inferior Vena Cava Filters.Seminars in interventional radiology · 2021Review
- Platelet factor 4 and β-thromboglobulin mRNAs in circulating microparticles of trauma patients as diagnostic markers for deep vein thrombosis.Journal of thrombosis and thrombolysis · 2020Article
- Post-traumatic pulmonary embolism: incidence, physiopathology, risk factors of early occurrence, and impact outcome. A narrative review.American journal of cardiovascular disease · 2020Review
- Venous thromboembolism prophylaxis and the impact of a thrombosis service at a Canadian level 1 trauma centreCanadian journal of surgery. Journal canadien de chirurgie · 2019Article
- The Effect of Deep Vein Thrombosis Prophylaxis on Bleeding in Periorbital Surgery in Trauma Patients.Craniomaxillofacial trauma & reconstruction · 2019Article
- Predicting contrast-induced nephropathy after CT pulmonary angiography in the critically ill: a retrospective cohort study.Journal of intensive care · 2018Article
- Characteristics of Mortalities related to Pulmonary Embolism following Multiple Trauma; a Brief Report.Emergency (Tehran, Iran) · 2018Article
- Effect of non-linearity of a predictor on the shape and magnitude of its receiver-operating-characteristic curve in predicting a binary outcome.Scientific reports · 2017Article
- Early intracardiac thrombus and pulmonary embolus after trauma.BMJ case reports · 2017Article
- Article
- Thromboembolic Disease after Cervical Spine Surgery: A Review of 5,405 Surgical Procedures and Matched Cohort Analysis.Global spine journal · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundVenous thromboembolism is common after major trauma. Strategies to prevent fatal pulmonary embolism (PE) are widely utilized, but the incidence and risk factors for fatal PE are poorly understood.
methodsUsing linked data from the intensive care unit, trauma registry, Western Australian Death Registry, and post-mortem reports, the incidence and risk factors for fatal PE in a consecutive cohort of major trauma patients, admitted between 1994 and 2002, were assessed. Non-linear relationships between continuous predictors and risk of fatal PE were modelled by logistic regression.
resultsOf the 971 consecutive trauma patients considered in the study, 134 (13.8%) died after their injuries. Fatal PE accounted for 11.9% of all deaths despite unfractionated heparin prophylaxis being used in 44% of these patients. Fatal PE occurred in those who were older (mean age 51- vs 37-yr-old, P=0.01), with more co-morbidities (Charlson's co-morbidity index 1.1 vs 0.2, P=0.01), had a larger BMI (31.8 vs 24.5, P=0.01), and less severe head and systemic injuries when compared with those who died of other causes. Sites of injuries were not significantly related to the risk of fatal PE. Fatal PE occurred much later than deaths from other causes (median 18 vs 2 days, P=0.01), and the estimated attributable mortality of PE was 49% (95% confidence interval 36-62%).
conclusionsFatal PE appeared to be a potential preventable cause of late mortality after major trauma. Severity of injuries, co-morbidity, and BMI were important risk factors for fatal PE after major trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.