Evidence map›Paper›PMID 20860763›Full record

ReviewOral diseases2011

At the edge of translation - materials to program cells for directed differentiation.

P R Arany, D J Mooney

Abstract readReview
In one paragraph

Review in Oral diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Cell and tissue engineering for liver disease.Science translational medicine · 2014
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P R AranyHarvard School of Engineering and Applied Sciences, Cambridge, MA, USA.
D J Mooney

Funding

ENGINEERING SKELETAL MUSCLE WITH BIODEGRADABLE HYDROGELSR01DE013349 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOONEY, DAVID J · 2000 to 2022
$9.3M
Polymeric Matrices with Defined Cell AdhesionR37DE013033 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOONEY, DAVID J · 2004 to 2013
$3.8M
NIDCR NIH HHS R01 DE013349NIDCR NIH HHS R37 DE013033
6 · The paper itself

Abstract

Oral Diseases (2011) 17, 241-251 The rapid advancement in basic biology knowledge, especially in the stem cell field, has created new opportunities to develop biomaterials capable of orchestrating the behavior of transplanted and host cells. Based on our current understanding of cellular differentiation, a conceptual framework for the use of materials to program cells in situ is presented, namely a domino vs a switchboard model, to highlight the use of single vs multiple cues in a controlled manner to modulate biological processes. Further, specific design principles of material systems to present soluble and insoluble cues that are capable of recruiting, programming and deploying host cells for various applications are presented. The evolution of biomaterials from simple inert substances used to fill defects, to the recent development of sophisticated material systems capable of programming cells in situ is providing a platform to translate our understanding of basic biological mechanisms to clinical care.

Indexed as

Biocompatible MaterialsCell AdhesionCell Adhesion MoleculesCell DifferentiationCell Physiological PhenomenaGuided Tissue RegenerationHumansIntercellular Signaling Peptides and ProteinsNucleic AcidsStem CellsTissue EngineeringBiocompatible MaterialsCell Adhesion MoleculesIntercellular Signaling Peptides and ProteinsNucleic Acids

Identifiers

PMID20860763
PMCPMC3049851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.