Evidence map›Paper›PMID 20860480›Full record

ReviewFuture microbiology2010

Type B coxsackieviruses and their interactions with the innate and adaptive immune systems.

Christopher C Kemball, Mehrdad Alirezaei, J Lindsay Whitton

Abstract readReview
In one paragraph

Review in Future microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Article
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  7. Review
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  11. Review
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  13. Antiviral Activity ofAntimicrobial agents and chemotherapy · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christopher C KemballDepartment of Immunology & Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mehrdad Alirezaei
J Lindsay Whitton

Funding

COXSACKIE MYOCARDITIS AND VIRAL PERSISTENCE IN THE HEARTR01AI042314 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 1998 to 2013
$5.6M
Innate and Adaptive Immune Responses in the Virus-Infected HeartR01HL093177 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI WHITTON, J. LINDSAY · 2010 to 2013
$1.9M
Evaluating dendritic cell activation and function during coxsackievirus infectionF32AI078660 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI KEMBALL, CHRISTOPHER CHARLES · 2009 to 2009
$52k
NHLBI NIH HHS HL093177NHLBI NIH HHS R01 HL093177NIAID NIH HHS F32 AI078660NIAID NIH HHS R01 AI042314
6 · The paper itself

Abstract

Coxsackieviruses are important human pathogens, and their interactions with the innate and adaptive immune systems are of particular interest. Many viruses evade some aspects of the innate response, but coxsackieviruses go a step further by actively inducing, and then exploiting, some features of the host cell response. Furthermore, while most viruses encode proteins that hinder the effector functions of adaptive immunity, coxsackieviruses and their cousins demonstrate a unique capacity to almost completely evade the attention of naive CD8(+) T cells. In this artcle, we discuss the above phenomena, describe the current status of research in the field, and present several testable hypotheses regarding possible links between virus infection, innate immune sensing and disease.

Indexed as

Adaptive ImmunityAnimalsAntibodies, ViralChildChild, PreschoolCoxsackievirus InfectionsEnterovirus B, HumanHost-Pathogen InteractionsHumansImmunity, InnateInfantInfant, NewbornT-LymphocytesAntibodies, Viral

Identifiers

PMID20860480
PMCPMC3045535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.