ReviewBirth defects research. Part C, Embryo today : reviews2010
Mechanobiology of embryonic skeletal development: Insights from animal models.
Review in Birth defects research. Part C, Embryo today : reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Computation of Fetal Kicking in Various Fetal Health Examinations: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Biophysical Stimuli: A Review of Electrical and Mechanical Stimulation in Hyaline Cartilage.Cartilage · 2019Pooled it
- Hip ontogenesis: how evolution, genes, and load history shape hip morphotype and cartilotype.Clinical orthopaedics and related research · 2012Pooled it
- Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in FGFR2 mouse models.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Effects of in ovo acrylamide injection on bone mineral composition and morphometric, geometric and mechanical parameters of femur and tibia bone of newly hatched chickens.Poultry science · 2026Article
- Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Altricial Patterns in Prenatal Skeletal Development of Two Large Neotropical Primates: The Poeppig's Woolly Monkey and the Juruá Red Howler Monkey.American journal of primatology · 2026Article
- Mechanoepigenetics in musculoskeletal disease.Osteoarthritis and cartilage · 2026Review
- Skeletal dysplasia-causing mutations in TRPV4 alter the chondrocyte transcriptomic response to mechanical loading.American journal of physiology. Cell physiology · 2025Article
- 3D-environment and muscle contraction regulate the heterogeneity of myonuclei.Skeletal muscle · 2024Article
- Immobilization secondary to cell death of muscle precursors with a dual transcriptional signature contributes to the emu wing skeletal pattern.Nature communications · 2024Article
- Material properties in regenerating axolotl limbs using inverse finite element analysis.Journal of the mechanical behavior of biomedical materials · 2024Article
- Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.PLoS computational biology · 2024Article
- A Review of the Role of Bioreactors for iPSCs-Based Tissue-Engineered Articular Cartilage.Tissue engineering and regenerative medicine · 2023Review
- Lack of skeletal muscle contraction disrupts fibrous tissue morphogenesis in the developing murine knee.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Mechanoregulatory role of TRPV4 in prenatal skeletal development.Science advances · 2023Article
- Building a Co-ordinated Musculoskeletal System: The Plasticity of the Developing Skeleton in Response to Muscle Contractions.Advances in anatomy, embryology, and cell biology · 2023Article
- Roadmap for an imaging and modelling paediatric study in rural NZ.Frontiers in physiology · 2023Article
- Synovial joint cavitation initiates with microcavities in interzone and is coupled to skeletal flexion and elongation in developing mouse embryo limbs.Biology open · 2022Article
- Local mechanical stimuli correlate with tissue growth in axolotl salamander joint morphogenesis.Proceedings. Biological sciences · 2022Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
A range of clinical conditions in which fetal movement is reduced or prevented can have a severe effect on skeletal development. Animal models have been instrumental to our understanding of the interplay between mechanical forces and skeletal development, particularly the mouse and the chick model systems. In the chick, the most commonly used means of altering the mechanical environment is by pharmaceutical agents which induce paralysis, whereas genetically modified mice with nonfunctional or absent skeletal muscle offer a valuable tool for examining the interplay between muscle forces and skeletogenesis in mammals. This article reviews the body of research on animal models of bone or joint formation in vivo in the presence of an altered or abnormal mechanical environment. In both immobilized chicks and "muscleless limb" mice, a range of effects are seen, such as shorter rudiments with less bone formation, changes in rudiment and joint shape, and abnormal joint cavitation. However, although all bones and synovial joints are affected in immobilized chicks, some rudiments and joints are unaffected in muscleless mice. We propose that extrinsic mechanical forces from movements of the mother or littermates impact on skeletogenesis in mammals, whereas the chick embryo is reliant on intrinsic movement for mechanical stimulation. The insights gained from animal models into the mechanobiology of embryonic skeletal development could provide valuable cues to prospective tissue engineers of cartilage and bone and contribute to new or improved treatments to minimize the impact on skeletal development of reduced movement in utero.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.