ArticleInternational journal of hematology2010
Transient abnormal myelopoiesis in a cytogenetically normal neonate.
Article in International journal of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Clinical characterization and genetic analysis of transient abnormal myelopoiesis without the down syndrome phenotype.Molecular genetics and metabolism reports · 2025Article
- Acute megakaryoblastic leukemia with acquired trisomy 21 and GATA1 mutations in phenotypically normal children.European journal of pediatrics · 2015Review
- Transient leukemia in a newborn without Down syndrome: case report and review of the literature.European journal of pediatrics · 2014Review
- Transient abnormal myelopoiesis in a phenotypically normal newborn with polyclonal trisomy 21.International journal of hematology · 2014Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a cytogenetically normal neonate who developed transient abnormal myelopoiesis. The blasts showed trisomy 21. In contrast, fibroblasts, and PHA-stimulated peripheral blood demonstrated normal diploid line on extensive karyotyping. Direct sequencing of the DNA derived from the peripheral blood at overt disease revealed splice site mutation in the boundary of GATA1 exon 2. The patient received three courses of chemotherapy leading to complete remission. During the complete remission, there was neither mutation of GATA1 exon 2 nor trisomy 21, confirming somatic nature of both abnormalities. The patient is now free from the disease 12 months after remission. This case emphasizes the significance of trisomy 21 as the cause of transient abnormal myelopoiesis in Down syndrome.
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Registered trials
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