ArticleJournal of clinical immunology2011
Primary immunodeficiencies: a 27-year review at a tertiary paediatric hospital in Cape Town, South Africa.
Article in Journal of clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 49 citations in OpenAlex.
- Genetic Characteristics of a Large Pediatric Cohort of Patients with Inborn Errors of Immunity: Single-Center Experience.Journal of clinical immunology · 2024Article
- Low incidence of primary immunodeficiency-associated cancers in children at a tertiary care pediatric hospital in Pakistan: a blessing in disguise or wet behind the ears?Ecancermedicalscience · 2024Article
- Inborn Errors of Immunity in Algerian Children and Adults: A Single-Center Experience Over a Period of 13 Years (2008-2021).Frontiers in immunology · 2022Article
- Infection in the Developing Brain: The Role of Unique Systemic Immune Vulnerabilities.Frontiers in neurology · 2021Review
- Hereditary Deficiency of the Second Component of Complement: Early Diagnosis and 21-Year Follow-Up of a Family.Medicina (Kaunas, Lithuania) · 2020Article
- A First Case Report of DiGeorge Syndrome from Ethiopia Highlights Challenges in Identifying and Treating Children with Primary T-Cell Deficiencies in Low Resource Settings.Case reports in immunology · 2020Article
- Primary Immunodeficiency Diseases in Oman: 10-Year Experience in a Tertiary Care Hospital.Journal of clinical immunology · 2016Article
- Invasive meningococcal disease in three siblings with hereditary deficiency of the 8(th) component of complement: evidence for the importance of an early diagnosis.Orphanet journal of rare diseases · 2016Article
- Report of the Tunisian Registry of Primary Immunodeficiencies: 25-Years of Experience (1988-2012).Journal of clinical immunology · 2015Review
- Primary immunodeficiency diseases in children: 15 year experience in a tertiary care medical center in Qatar.Journal of clinical immunology · 2013Article
- The prevalences [correction] and patient characteristics of primary immunodeficiency diseases in Turkey--two centers study.Journal of clinical immunology · 2013Article
- Are inborn errors of immunity being investigated in the pediatric intensive care unit?Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe epidemiology of primary immunodeficiencies (PID) is not well documented in Africa. The objective of this study was to describe the spectrum of PID at a tertiary paediatric centre in South Africa.
methodsA retrospective study was conducted on 168 patients diagnosed with PID from 1983 to 2009.
resultsOver the study period, antibody deficiencies predominated (51%) followed by well-defined syndromes (24%). Common variable immunodeficiency was the commonest antibody deficiency. The mean age of diagnosis was 51 months overall but decreased significantly to 35 months over the last 9 years. Recurrent infections were the most common presenting complaint (74%). The overall mortality rate was 25% while combined immunodeficiencies accounted for 40% of the deaths.
conclusionsThe spectrum of PID in South Africa was similar to international trends. The declining mean age of diagnosis indicated improved recognition of PID. Future research should focus on identifying children with PID more effectively.
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