ArticleDiabetologia2010
Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes.
Article in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Non-pharmacological Intervention Study for Prevention of Ischaemic Heart Disease Inter99
Twenty-year Follow-up of the Inter99 Cohort
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Long term endocrine issues in adults born prematurely: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta-Analysis of 7 646 267 Participants From 135 Studies.Journal of the American Heart Association · 2018Pooled it
- Smaller birth size may be associated with lower physical activity in adult women.Scientific reports · 2025Article
- Association of hypertensive disorders of pregnancy and gestational diabetes mellitus with developing severe retinopathy of prematurity.International journal of retina and vitreous · 2025Article
- Interaction effect between low birthweight and resistin gene rs1862513 variant on insulin resistance and type 2 diabetes mellitus in adulthood: Toon Genome Study.Journal of diabetes investigation · 2024Article
- Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort.BMJ open · 2024Article
- Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition.Diabetologia · 2023Article
- Associations of maternal preterm birth with subsequent risk for type 2 diabetes in women from the women's health initiative.Journal of developmental origins of health and disease · 2023Article
- Low Birth Weight, β-Cell Function and Insulin Resistance in Adults: The Brazilian Longitudinal Study of Adult Health.Frontiers in endocrinology · 2022Article
- Improving long-term health outcomes of preterm infants: how to implement the findings of nutritional intervention studies into daily clinical practice.European journal of pediatrics · 2021Review
- Anti-epileptic drug exposure during pregnancy and neonatal birth weight outcomes: protocol for a systematic review and meta-analysis.Systematic reviews · 2021Article
- Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study.Journal of diabetes investigation · 2020Article
- Mortality Rate and Major Causes of Death by Gestational Age in Korean Children under 5 Years of Age.Journal of Korean medical science · 2020Article
- Article
- Diabetes in South Asians: Phenotype, Clinical Presentation, and Natural History.Current diabetes reports · 2018Review
- Early postnatal nutrition after preterm birth and cardiometabolic risk factors in young adulthood.PloS one · 2018Article
- Article
- ELBW survivors in early adulthood have higher hepatic, pancreatic and subcutaneous fat.Scientific reports · 2016Article
- All-Cause Mortality of Low Birthweight Infants in Infancy, Childhood, and Adolescence: Population Study of England and Wales.PLoS medicine · 2016Article
- Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.Diabetologia · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
aims/hypothesisWe studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237).
methodsInformation about size at birth and prematurity was identified from original midwife records in 4,744 middle-aged Danes. Type 2 diabetes status, insulin sensitivity (Matsuda index) and beta cell function (disposition index) were assessed using a 75 g oral glucose tolerance test. Participants born prematurely were compared with a group of at-term participants born small for gestational age.
resultsAn increase in birthweight of 1 kg was associated with a 51% (OR 0.49, 95% CI 0.35-0.69) reduced risk of type 2 diabetes. Ponderal index, reflecting thinness at birth, was associated with type 2 diabetes to the same extent as birthweight. The prevalence of type 2 diabetes was increased to a similar degree in participants born prematurely and participants born small for gestational age, although the former had a higher ponderal index at birth. In addition, birthweight z-scores, reflecting fetal growth rate, were unrelated to the risk of type 2 diabetes and to other measures of glucose regulation in participants born prematurely. While low birthweight was inversely associated with insulin sensitivity and beta cell function, prematurity was associated solely with decreased insulin sensitivity. CONCLUSIONS/
interpretationWhile the association between birthweight and risk of type 2 diabetes is mediated via combined effects on beta cell function and insulin sensitivity, prematurity seems to influence risk of type 2 diabetes via attenuated insulin sensitivity only and independently of fetal growth rates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.