ArticleFrontiers in neuroscience2010
Closed-loop, open-source electrophysiology.
Article in Frontiers in neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Microelectrode arrays cultured with in vitro neural networks for motion control tasks: encoding and decoding progress and advances.Microsystems & nanoengineering · 2025Review
- Modulation of neuronal dynamics by sustained and activity-dependent continuous-wave near-infrared laser stimulation.Neurophotonics · 2024Article
- A field-programmable gate array (FPGA)-based data acquisition system for closed-loop experiments.The Review of scientific instruments · 2022Article
- Advances in Neural Recording and Stimulation Integrated Circuits.Frontiers in neuroscience · 2021Review
- Control of cortical oscillatory frequency by a closed-loop system.Journal of neuroengineering and rehabilitation · 2019Article
- A Biohybrid Setup for Coupling Biological and Neuromorphic Neural Networks.Frontiers in neuroscience · 2019Article
- Cost-effective and multifunctional acquisition system for in vitro electrophysiological investigations with multi-electrode arrays.PloS one · 2019Article
- Development of Cortical Networks under Continuous Stimulation.Frontiers in molecular neuroscience · 2017Article
- An FPGA Platform for Real-Time Simulation of Spiking Neuronal Networks.Frontiers in neuroscience · 2017Article
- Closed Loop Experiment Manager (CLEM)-An Open and Inexpensive Solution for Multichannel Electrophysiological Recordings and Closed Loop Experiments.Frontiers in neuroscience · 2017Article
- Neuroelectronics and Biooptics: Closed-Loop Technologies in Neurological Disorders.JAMA neurology · 2015Review
- Toward Building Hybrid Biological/in silico Neural Networks for Motor Neuroprosthetic Control.Frontiers in neurorobotics · 2015Article
- A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology.Frontiers in neuroinformatics · 2015Article
- Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus.eLife · 2014Article
- ACQ4: an open-source software platform for data acquisition and analysis in neurophysiology research.Frontiers in neuroinformatics · 2014Article
- A CMOS IC-based multisite measuring system for stimulation and recording in neural preparations in vitro.Frontiers in neuroengineering · 2014Article
- Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiologic recording with NeuroRighter.Frontiers in neuroengineering · 2014Article
- Controlling neural network responsiveness: tradeoffs and constraints.Frontiers in neuroengineering · 2014Article
- The response clamp: functional characterization of neural systems using closed-loop control.Frontiers in neural circuits · 2013Review
- Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays.Frontiers in neural circuits · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Multiple extracellular microelectrodes (multi-electrode arrays, or MEAs) effectively record rapidly varying neural signals, and can also be used for electrical stimulation. Multi-electrode recording can serve as artificial output (efferents) from a neural system, while complex spatially and temporally targeted stimulation can serve as artificial input (afferents) to the neuronal network. Multi-unit or local field potential (LFP) recordings can not only be used to control real world artifacts, such as prostheses, computers or robots, but can also trigger or alter subsequent stimulation. Real-time feedback stimulation may serve to modulate or normalize aberrant neural activity, to induce plasticity, or to serve as artificial sensory input. Despite promising closed-loop applications, commercial electrophysiology systems do not yet take advantage of the bidirectional capabilities of multi-electrodes, especially for use in freely moving animals. We addressed this lack of tools for closing the loop with NeuroRighter, an open-source system including recording hardware, stimulation hardware, and control software with a graphical user interface. The integrated system is capable of multi-electrode recording and simultaneous patterned microstimulation (triggered by recordings) with minimal stimulation artifact. The potential applications of closed-loop systems as research tools and clinical treatments are broad; we provide one example where epileptic activity recorded by a multi-electrode probe is used to trigger targeted stimulation, via that probe, to freely moving rodents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.