Evidence map›Paper›PMID 20859299›Full record

Trial reportEuropean journal of clinical nutrition2011

Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers.

D Mahalingam, A K Radhakrishnan, Z Amom, N Ibrahim, K Nesaretnam

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01571921 (Phase 1a), which is not on this map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01571921 phase1completednot on this mapstarted 2013, after this paper: background citation

Phase 1a: A Randomized, 2-period Cross-over Study to Compare the Bioavailability of Gamma-Delta Tocotrienol (GDT) With That of Tocotrienol Rich Fraction (TRF) in Twelve Healthy Subjects

TypeinterventionalSponsorMalaysia Palm Oil BoardRan2013 to 2013Enrolled12ConditionsHealthy SubjectsArmsGamma-Delta Tocotrienol and Tocotrienol Rich Fraction
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  16. Article
  17. Vitamin E beyond Its Antioxidant Label.Antioxidants (Basel, Switzerland) · 2021
    Review
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

D MahalingamMalaysian Palm Oil Board, Selangor, Malaysia.
A K Radhakrishnan
Z Amom
N Ibrahim
K Nesaretnam
International Medical University · MYMalaysian Palm Oil Board · MYUniversiti Putra Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesVitamin E is an essential fat-soluble vitamin that has been shown to induce favorable effects on animal and human immune systems. The objective of this study was to assess the effects of tocotrienol-rich fraction (TRF) supplementation on immune response following tetanus toxoid (TT) vaccine challenge in healthy female volunteers. SUBJECTS/

methodsIn this double-blinded, placebo-controlled clinical trial, participants were randomly assigned to receive either placebo (control group) or 400 mg of TRF (study group) supplementation daily. Over the 2-month period of the study, volunteers were asked to attend three clinical sessions (that is, on days 0, 28 and 56) and blood samples were obtained from the volunteers during the follow-up. On day 28, all volunteers were also vaccinated with the TT vaccine (20 Lf) intramuscularly.

resultsThe results from the clinical trial showed that TRF supplementation significantly increased the total vitamin E level in the plasma of the TRF-supplemented volunteers compared with the placebo group, indicating overall compliance. Volunteers supplemented with TRF showed a significantly (P < 0.05) enhanced production of interferon-γ and interleukin (IL)-4 by the mitogen or TT-stimulated leukocytes compared with the control group. Volunteers from the TRF group produced significantly (P < 0.05) lower amounts of IL-6 compared with the placebo group. Anti-TT IgG production was also significantly (P < 0.05) augmented in the TRF-supplemented group compared with the placebo group.

conclusionsWe conclude that TRF has immunostimulatory effects and potential clinical benefits to enhance immune response to vaccines.

Indexed as

Dietary SupplementsAdjuvants, ImmunologicAdolescentAdultAntibodies, BacterialDouble-Blind MethodFemaleFollow-Up StudiesHumansImmunoglobulin GInterferon-gammaInterleukin-4Interleukin-6Tetanus ToxoidTocotrienolsVaccinationAdjuvants, ImmunologicAntibodies, BacterialIL4 protein, humanIL6 protein, humanImmunoglobulin GInterferon-gammaInterleukin-4Interleukin-6Tetanus ToxoidTocotrienols

Identifiers

PMID20859299
OpenAlexW2004808149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.