ArticleAIDS (London, England)2010
Fracture incidence in HIV-infected women: results from the Women's Interagency HIV Study.
Article in AIDS (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- People with HIV infection had lower bone mineral density and increased fracture risk: a meta-analysis.Archives of osteoporosis · 2021Pooled it
- Bone fracture among people living with HIV: A systematic review and meta-regression of prevalence, incidence, and risk factors.PloS one · 2020Pooled it
- Diagnosis, prevention, and treatment of bone fragility in people living with HIV: a position statement from the Swiss Association against Osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Guideline
- Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis.AIDS (London, England) · 2014Pooled it
- The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.PloS one · 2014Pooled it
- Incident fractures in HIV-infected individuals: a systematic review and meta-analysis.AIDS (London, England) · 2013Pooled it
- Bone Density and Fractures in HIV-infected Postmenopausal Women: A Systematic Review.The Journal of the Association of Nurses in AIDS Care : JANACPooled it
- Associations between vitamin D metabolites, antiretroviral therapy and bone mineral density in people with HIV.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Trial
- Narrative Review on the Management of Neck of Femur Fractures in People Living with HIV: Challenges, Complications, and Long-Term Outcomes.Microorganisms · 2025Review
- Breaking Down Bone Disease in People Living with HIV: Pathophysiology, Diagnosis, and Treatment.Advances in experimental medicine and biology · 2025Review
- Article
- Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus.Open forum infectious diseases · 2021Review
- Incident bone fracture and mortality in a large HIV cohort outpatient study, 2000-2017, USA.Archives of osteoporosis · 2021Article
- Human immunodeficiency virus infection (HIV)-associated rheumatic manifestations in thepre- and post-HAART eras.Clinical rheumatology · 2020Review
- Smoking and cessation treatment among persons with and without HIV in a U.S. integrated health system.Drug and alcohol dependence · 2020Article
- Alcohol and Bone Turnover Markers among People Living with HIV and Substance Use Disorder.Alcoholism, clinical and experimental research · 2020Article
- Relationship Between Vertebral Fractures, Bone Mineral Density, and Osteometabolic Profile in HIV and Hepatitis B and C-Infected Patients Treated With ART.Frontiers in endocrinology · 2019Article
- An increased rate of fracture occurs a decade earlier in HIV+ compared with HIV- men.AIDS (London, England) · 2017Article
- Factors associated with fractures in HIV-infected persons: which factors matter?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Bone health in HIV and hepatitis B or C infections.Therapeutic advances in musculoskeletal disease · 2017Review
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11 authors.
Funding
Abstract
backgroundThe clinical importance of the association of HIV infection and antiretroviral therapy (ART) with low bone mineral density (BMD) in premenopausal women is uncertain because BMD stabilizes on established ART and fracture data are limited.
methodsWe measured time to first new fracture at any site with median follow-up of 5.4 years in 2391 (1728 HIV-infected, 663 HIV-uninfected) participants in the Women's Interagency HIV Study (WIHS). Self-report of fracture was recorded at semiannual visits. Proportional hazard models assessed predictors of incident fracture.
resultsAt baseline, HIV-infected women were older (40 ± 9 vs. 36 ± 10 years, P < 0.0001), more likely to report postmenopausal status and be hepatitis C virus-infected, and weighed less than HIV-uninfected women. Among HIV-infected women, mean CD4(+) cell count was 482 cells/μl; 66% were taking ART. Unadjusted incidence of fracture did not differ between HIV-infected and uninfected women (1.8 vs. 1.4/100 person-years, respectively, P = 0.18). In multivariate models, white (vs. African-American) race, hepatitis C virus infection, and higher serum creatinine, but not HIV serostatus, were statistically significant predictors of incident fracture. Among HIV-infected women, older age, white race, current cigarette use, and history of AIDS-defining illness were associated with incidence of new fracture.
conclusionAmong predominantly premenopausal women, there was little difference in fracture incidence rates by HIV status, rather traditional risk factors were important predictors. Further research is necessary to characterize fracture risk in HIV-infected women during and after the menopausal transition.
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