SynthesisCirculation. Cardiovascular genetics2010
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.
Synthesis in Circulation. Cardiovascular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Genetic association between the lncRNA ANRIL rs10757272 polymorphism and intracranial aneurysm susceptibility in Asians.Neurosurgical review · 2022Pooled it
- Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.Circulation. Cardiovascular genetics · 2012Pooled it
- Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21.BMC cardiovascular disorders · 2012Trial
- Clonal hematopoiesis of indeterminate potential (CHIP), vascular somatic mutation, and cardiovascular disease: A narrative review.Vascular medicine (London, England) · 2026Review
- Genetic Association Study and Machine Learning to Investigate Differences in Platelet Reactivity in Patients with Acute Ischemic Stroke Treated with Aspirin.Biomedicines · 2022Article
- Effects of CDKN2B-AS1 polymorphisms on the susceptibility to coronary heart disease.Molecular genetics & genomic medicine · 2019Article
- Genome-wide association study of coronary artery calcification in asymptomatic Korean populations.PloS one · 2019Article
- Relevance of Multi-Omics Studies in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2019Review
- From Genotype to Phenotype: A Primer on the Functional Follow-up of Genome-Wide Association Studies in Cardiovascular Disease.Circulation. Genomic and precision medicine · 2018Article
- Long Noncoding RNAFrontiers in cardiovascular medicine · 2018Review
- Multiple thrombophilia mutations as a possible cause of premature myocardial infarction.Wiener klinische Wochenschrift · 2017Article
- Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr-/-, Cdkn2a-Deficient Mice.Circulation. Cardiovascular genetics · 2016Article
- The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3.BMC medical genetics · 2014Article
- Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?Current cardiology reports · 2014Review
- Article
- Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk.Circulation. Cardiovascular genetics · 2013Article
- Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study.Circulation · 2013Article
- VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification.Human genetics · 2013Article
- Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15).Cardiovascular diabetology · 2012Article
- Platelet signaling.Handbook of experimental pharmacology · 2012Review
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Authors and funding
22 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundGenome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations. METHODS AND
resultsSubjects in the initial population included 1402 asymptomatic Amish adults in whom we measured platelet reactivity (n=788) and coronary artery calcification (CAC) (n=939). Platelet reactivity on agonist stimulation was measured by impedance aggregometry, and CAC was measured by electron beam CT. Twenty-nine SNPs at the 9p21.3 locus were genotyped using the Affymetrix 500K array. Twelve correlated SNPs in the locus were significantly associated with platelet reactivity (all P≤0.001). The SNP most strongly associated with platelet reactivity, rs10965219 (P=0.0002), also was associated with CAC (P=0.002) along with 9 other SNPs (all P<0.004). Association of rs10965219 with platelet reactivity persisted after adjustment for CAC, a measure of underlying atherosclerotic burden known to affect platelet reactivity. We then tested rs10965219 for association with platelet function in 2364 subjects from the Framingham Heart Study and 1169 subjects from the Genetic Study of Aspirin Responsiveness. The rs10965219 G allele (frequency ≈51% across all 3 populations) was significantly associated with higher platelet reactivity in the Framingham Heart Study (P=0.001) and trended toward higher reactivity in the Genetic Study of Aspirin Responsiveness (P=0.087); the combined P value for metaanalysis was 0.0002.
conclusionsThese results suggest that risk alleles at 9p21.3 locus may have pleiotropic effects on myocardial infarction/coronary artery disease and stroke risk, possibly through their influence on platelet reactivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.