Evidence map›Paper›PMID 20858520›Full record

ReviewAdvanced drug delivery reviews2010

Development and applications of photo-triggered theranostic agents.

Prakash Rai, Srivalleesha Mallidi, Xiang Zheng, Ramtin Rahmanzadeh, Youssef Mir, Stefan Elrington, Ahmat Khurshid, Tayyaba Hasan

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Design strategy of hydrogel wound dressings based on oral special environment.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024
    Article
  8. Review
  9. Review
  10. Natural Sunlight-Mediated Emodin Photoinactivation ofInternational journal of molecular sciences · 2024
    Article
  11. Review
  12. Cellular Mechanisms of Singlet Oxygen in Photodynamic Therapy.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Bio-nanocomplexes with autonomous OJournal of nanobiotechnology · 2022
    Article
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prakash RaiWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, United States.
Srivalleesha Mallidi
Xiang Zheng
Ramtin Rahmanzadeh
Youssef Mir
Stefan Elrington
Ahmat Khurshid
Tayyaba Hasan

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Bryan Quilty Spring · 2001 to 2026
$27.9M
Targeted Smart Nanoplatforms for Multimode ImagingP50CA128346 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STUPACK, DWAYNE G. · 2008 to 2012
$6.9M
Photodestruction of Ovarian Cancer: ErbB3 Targeted Aptamer Nanoparticle ConjugateR01CA119388 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HASAN, TAYYABA · 2005 to 2009
$2.6M
Real Time, Automated Singlet Oxygen Dosimeter for PDTR44CA128364 · NCI · PHYSICAL SCIENCES, INC · PI DAVIS, STEVEN J · 2007 to 2009
$1.2M
Targeted Photoactivatable Nanocells to Image and Treat Metastic Ovarian CancerRC1CA146337 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HASAN, TAYYABA · 2009 to 2010
$971k
NCI NIH HHS P01 CA084203NCI NIH HHS P50 CA128346NCI NIH HHS R01 CA119388NCI NIH HHS R44CA128364NCI NIH HHS RC1 CA146337
6 · The paper itself

Abstract

Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases.

Indexed as

AnimalsAnti-Infective AgentsAntineoplastic AgentsDiagnostic ImagingDrug CarriersHumansInfectionsNanoparticlesNeoplasmsPhototherapyAnti-Infective AgentsAntineoplastic AgentsDrug Carriers

Identifiers

PMID20858520
PMCPMC2991599

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.