ArticleDevelopmental biology2010
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.Molecular biology of the cell · 2024Article
- Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish.Human molecular genetics · 2024Article
- Mechanically sensitive HSF1 is a key regulator of left-right symmetry breaking in zebrafish embryos.iScience · 2023Article
- Article
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- Identification of colon tumor marker NKD1 via integrated bioinformatics analysis and experimental validation.Cancer medicine · 2021Article
- Getting to the Heart of Left-Right Asymmetry: Contributions from the Zebrafish Model.Journal of cardiovascular development and disease · 2021Review
- Article
- Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs.Developmental biology · 2020Article
- Review
- The polycystin complex mediates Wnt/Ca(2+) signalling.Nature cell biology · 2016Article
- Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning.Biology open · 2015Article
- Wnt ligand-dependent activation of the negative feedback regulator Nkd1.Molecular biology of the cell · 2015Article
- Itch is required for lateral line development in zebrafish.PloS one · 2014Article
- Article
- Dvr1 transfers left-right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish.Developmental biology · 2013Article
- A unified model for left-right asymmetry? Comparison and synthesis of molecular models of embryonic laterality.Developmental biology · 2013Review
- Network topologies and convergent aetiologies arising from deletions and duplications observed in individuals with autism.PLoS genetics · 2013Article
- Analysis of gene function and visualization of cilia-generated fluid flow in Kupffer's vesicle.Journal of visualized experiments : JoVE · 2013Article
- Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The establishment of the left-right (LR) axis in zebrafish embryos relies on signals from the dorsal forerunner cells (DFC) and the Kupffer's vesicle (KV). While the Wnt signaling network influences many aspects of embryonic development, its precise role in LR patterning is still unclear. One branch of the Wnt network leads to stabilization of β-catenin and activation of downstream target genes. Other Wnt ligands appear to act independently of β-catenin to modulate calcium release and influence cell polarity. Central to regulation of β-catenin and coordination of convergent extension (CE) movements is Dishevelled (Dvl). Naked Cuticle (Nkd) binds Dvl and modulates β-catenin-dependent and independent Wnt signaling. Here, we analyze the expression patterns of three zebrafish Nkd homologs and find enriched expression of nkd1 in DFCs and KV. Dvl is degraded upon Nkd1 overexpression in zebrafish. Knockdown of Nkd1 specifically in the DFC results in β-catenin nuclear localization and transcriptional activation as well as alterations to DFC migration, KV formation, ciliogenesis and LR patterning. Furthermore, we identify asymmetric expression of the Nodal antagonist charon around the KV and show that Nkd1 knockdown impacts asymmetric charon expression. Our findings show that Nkd1 acts as a β-catenin antagonist in the DFCs necessary for LR patterning.
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