ArticleBiochemical and biophysical research communications2010
The obesity-associated Fto gene is a transcriptional coactivator.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 118 citations in OpenAlex.
- FTO-Mediated m6A Demethylation in Insulin Resistance and Type 2 Diabetes: Tissue-Specific Mechanisms - a Narrative Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Regulation of feeding and metabolism by fat mass and obesity-associated protein in zebrafish.Scientific reports · 2025Article
- Article
- Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding.Nutrients · 2024Review
- Association of FTO gene variant rs9939609 with polycystic ovary syndrome from Gujarat, India.BMC medical genomics · 2023Article
- Review
- Long-term exercise training down-regulates mBMC neuroscience · 2022Article
- The m6A(m)-independent role of FTO in regulating WNT signaling pathways.Life science alliance · 2022Article
- Association between theNutrients · 2021Article
- Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?International journal of molecular sciences · 2021Review
- Changes in N6-Methyladenosine Modification Modulate Diabetic Cardiomyopathy by Reducing Myocardial Fibrosis and Myocyte Hypertrophy.Frontiers in cell and developmental biology · 2021Article
- Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6-Methyladenosine-Mediated Post-Transcriptional Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- FTO is a transcriptional repressor to auto-regulate its own gene and potentially associated with homeostasis of body weight.Journal of molecular cell biology · 2019Article
- RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.Frontiers in cardiovascular medicine · 2019Review
- Evaluation ofOman medical journal · 2019Article
- Fat Mass and Obesity Associated (Nutrients · 2018Review
- FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.Journal of lipid research · 2018Article
- Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.Endocrine · 2018Article
- The (FTO) gene polymorphism is associated with metabolic syndrome risk in Egyptian females: a case- control study.BMC medical genetics · 2017Article
- Complex Relationship between Obesity and the Fat Mass and Obesity Locus.International journal of biological sciences · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The fat mass and obesity associated, FTO, gene has been shown to be associated with obesity in human in several genome-wide association scans. In vitro studies suggest that Fto may function as a single-stranded DNA demethylase. In addition, homologous recombination-targeted knockout of Fto in mice resulted in growth retardation, loss of white adipose tissue, and increase energy metabolism and systemic sympathetic activation. Despite these intense investigations, the exact function of Fto remains unclear. We show here that Fto is a transcriptional coactivator that enhances the transactivation potential of the CCAAT/enhancer binding proteins (C/EBPs) from unmethylated as well as methylation-inhibited gene promoters. Fto also exhibits nuclease activity. We showed further that Fto enhances the binding C/EBP to unmethylated and methylated DNA. The coactivator role of FTO in modulating the transcriptional regulation of adipogenesis by C/EBPs is consistent with the temporal progressive loss of adipose tissue in the Fto-deficient mice, thus suggesting a role for Fto in the epigenetic regulation of the development and maintenance of fat tissue. How FTO reactivates transcription from methyl-repressed gene needs to be further investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.