ArticleBiophysical journal2010
Significant impact on muscle mechanics of small nonlinearities in myofilament elasticity.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- The effects of inorganic phosphate on muscle force development and energetics: challenges in modelling related to experimental uncertainties.Journal of muscle research and cell motility · 2021Article
- The Location and Rate of the Phosphate Release Step in the Muscle Cross-Bridge Cycle.Biophysical journal · 2020Article
- Myosin Cross-Bridge Behaviour in Contracting Muscle-The TInternational journal of molecular sciences · 2019Article
- Nonlinear Actomyosin Elasticity in Muscle?Biophysical journal · 2019Article
- Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?International journal of molecular sciences · 2018Review
- Temperature Effects on Force and Actin⁻Myosin Interaction in Muscle: A Look Back on Some Experimental Findings.International journal of molecular sciences · 2018Review
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- The contributions of filaments and cross-bridges to sarcomere compliance in skeletal muscle.The Journal of physiology · 2014Article
- Stiffness, working stroke, and force of single-myosin molecules in skeletal muscle: elucidation of these mechanical properties via nonlinear elasticity evaluation.Cellular and molecular life sciences : CMLS · 2013Review
- Mechanism of force enhancement during stretching of skeletal muscle fibres investigated by high time-resolved stiffness measurements.Journal of muscle research and cell motility · 2013Article
- Translational actomyosin research: fundamental insights and applications hand in hand.Journal of muscle research and cell motility · 2012Review
- Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing.Journal of muscle research and cell motility · 2010Review
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1 author at 1 institution in 1 country.
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Abstract
Important mechanisms in muscle contraction have recently been reevaluated based on analyses that rely on the assumption of linear myofilament elasticity. However, the present theoretical study shows that nonlinearity of this elasticity, even when so minor that it may be difficult to detect in experimental data, could have great impact on the interpretation of muscle mechanical experiments. This is illustrated by using simulated stiffness and strain-versus-force data for muscle fibers shortening at different constant velocities. There is substantial quantitative agreement, for this condition, between models with distributed myofilament compliance and models where the compliance of the myofilaments and the actomyosin cross-bridges are lumped together into two separate elastic elements acting in series. The data thus support the usefulness of the latter, simpler, type of model in the analysis. However, most importantly, the data emphasize the importance of caution before reevaluating fundamental mechanisms of muscle contraction based on analyses relying on the assumption of linear myofilament elasticity.
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