ArticleBiophysical journal2010
Nonessential sites improve phosphorylation switch.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Intrinsic Disorder in the T Cell Receptor Creates Cooperativity and Controls ZAP70 Binding.Biophysical journal · 2021Article
- The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions.Biophysical journal · 2019Article
- A Tie2 kinase mutation causing venous malformations increases phosphorylation rates and enhances cooperativity.Biochemical and biophysical research communications · 2019Article
- Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication.Molecular biology of the cell · 2018Article
- Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression.Science advances · 2017Article
- The effect of site-to-site variability in ultrasensitive dose responses.Journal of mathematical biology · 2017Article
- Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.Biophysical journal · 2016Article
- The Prozone Effect Accounts for the Paradoxical Function of the Cdk-Binding Protein Suc1/Cks.Cell reports · 2016Article
- Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function.Science signaling · 2015Article
- Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback.Trends in biochemical sciences · 2014Review
- Ultrasensitivity in independent multisite systems.Journal of mathematical biology · 2014Article
- Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs).Chemical reviews · 2014Review
- Enhancement of tunability of MAPK cascade due to coexistence of processive and distributive phosphorylation mechanisms.Biophysical journal · 2014Article
- Compact modeling of allosteric multisite proteins: application to a cell size checkpoint.PLoS computational biology · 2014Article
- Article
- Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations.Papers in physics · 2014Article
- Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors.Theoretical biology & medical modelling · 2013Article
- Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.PLoS computational biology · 2013Article
- Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate.PLoS computational biology · 2013Article
- Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts.Nature protocols · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Multisite phosphorylation is a common form of posttranslational protein regulation which has been used to increase the switchlike behavior of the protein response to increasing kinase concentrations. In this letter, we show that the switchlike response of multisite phosphoproteins is strongly enhanced by nonessential phosphorylation sites, a mechanism that is robust to parameter changes and easily implemented in nature. We obtained analytic estimates for the Hill exponent (or coefficient) of the switchlike response, and we observed that a tradeoff exists between the switch and the kinase threshold for activation. This also suggests a possible evolutionary mechanism for the relatively large numbers of phosphorylation sites found in various proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.