Evidence map›Paper›PMID 20858280›Full record

Trial reportBMC infectious diseases2010

Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial.

Patrick Kirwan, Andrew L Jackson, Samuel O Asaolu, Sile F Molloy, Titilayo C Abiona, Marian C Bruce, Lisa Ranford-Cartwright, Sandra M O' Neill, Celia V Holland

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 7 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 7 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Anthelmintic drugs for treating ascariasis.The Cochrane database of systematic reviews · 2020
    Pooled it
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  8. Trial
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  15. Article
  16. Review
  17. Twenty-year economic impacts of deworming.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Repurposing Drugs to Fight Hepatic Malaria Parasites.Molecules (Basel, Switzerland) · 2020
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Patrick KirwanDepartment of Zoology, University of Dublin, Trinity College, Dublin 2, Ireland. kirwanpa@tcd.ie
Andrew L Jackson
Samuel O Asaolu
Sile F Molloy
Titilayo C Abiona
Marian C Bruce
Lisa Ranford-Cartwright
Sandra M O' Neill
Celia V Holland
Trinity College Dublin · IEUniversity of Glasgow · GBChicago State University · USDublin City University · IEObafemi Awolowo University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children.

methodsA double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months. Children were randomly assigned to receive either albendazole or placebo every four months for 12 months with a follow-up at 14 months.

results320 Children (out of 1228, 26.1%) complied with all the follow-up assessments. Plasmodium prevalence and mean Plasmodium parasite density was significantly higher in the treatment group (44.9% and 2319 ± SE 511) compared to the placebo group (33.3% and 1471 ± 341) at baseline. The odds of having Plasmodium infection increased over time for children in both the placebo and treatment groups, however this increase was significantly slower for children in the treatment group (P = 0.002). By month 14, mean Plasmodium density had increased by 156% in the placebo group and 98% in the treatment group but the rate of change in Plasmodium density was not significantly different between the groups. The change from baseline in haemoglobin had a steeper increase among children in the treatment group when compared to the placebo group but this was not statistically significant.

conclusionsRepeated four-monthly anthelminthic treatments for 14 months resulted in a significantly lower increase in the prevalence of Plasmodium infection in preschool children which coincided with a reduction in both the prevalence and intensity of A. lumbricoides infections.

trial registrationCurrent controlled trials ISRCTN44215995.

Indexed as

AlbendazoleAnimalsAnthelminticsAscariasisAscaris lumbricoidesChild, PreschoolDouble-Blind MethodFemaleHumansInfantMalariaMalePlacebosTreatment OutcomeAlbendazoleAnthelminticsPlacebos

Identifiers

PMID20858280
PMCPMC3161357
OpenAlexW2077246963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.