Evidence map›Paper›PMID 20858228›Full record

ArticleLipids in health and disease2010

The association between blood glucose and oxidized lipoprotein(a) in healthy young women.

Kazuhiko Kotani, Shingo Yamada, Shuumarjav Uurtuya, Toshiyuki Yamada, Nobuyuki Taniguchi, Ikunosuke Sakurabayashi

Abstract read
In one paragraph

Article in Lipids in health and disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kazuhiko KotaniDepartment of Clinical Laboratory Medicine, Jichi Medical University, Tochigi, Japan. kazukotani@jichi.ac.jp
Shingo Yamada
Shuumarjav Uurtuya
Toshiyuki Yamada
Nobuyuki Taniguchi
Ikunosuke Sakurabayashi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidized lipoproteins play important roles in the atherosclerotic processes. Oxidized lipoprotein(a) (oxLp(a)) may be more potent in atherosclerotic pathophysiology than native Lp(a), a cardiovascular disease-relevant lipoprotein. Increased blood glucose concentrations can induce oxidative modification of lipoproteins. The aim of this study was to investigate the association between circulating oxLp(a) and cardiometabolic variables including blood glucose in healthy volunteers within the normal range of blood glucose.

methodsSeveral cardiometabolic variables and serum oxLp(a) (using an ELISA system) were measured among 70 healthy females (mean age, 22 years).

resultsLp(a) and glucose were significantly and positively correlated with oxLp(a) in simple correlation test. Furthermore, a multiple linear regression analysis showed oxLp(a) to have a weakly, but significantly positive and independent correlation with only blood glucose (β = 0.269, P < 0.05).

conclusionsThese results suggest that increased glucose may enhance the oxidization of Lp(a) even at normal glucose levels.

Indexed as

AdolescentAdultApoprotein(a)AtherosclerosisBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesEarly DiagnosisFemaleHumansLipidsLipoprotein(a)LipoproteinsOxidation-ReductionRisk FactorsApoprotein(a)Blood GlucoseLipidsLipoprotein(a)Lipoproteins

Identifiers

PMID20858228
PMCPMC2949859

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.