ArticleSleep2010
Energy expenditure is affected by rate of accumulation of sleep deficit in rats.
Article in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Alterations in gut microbiota and metabolites contribute to postoperative sleep disturbances.Animal models and experimental medicine · 2025Article
- Signals of energy availability in sleep: consequences of a fat-based metabolism.Frontiers in nutrition · 2024Review
- Chronic sleep restriction during juvenility alters hedonic and anxiety-like behaviours in a sex-dependent fashion in adolescentFrontiers in neuroscience · 2024Article
- Neurofibromin 1 mediates sleep depth in Drosophila.PLoS genetics · 2023Article
- Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs ineLife · 2023Article
- Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs inbioRxiv : the preprint server for biology · 2023Article
- Sleep loss impairs intestinal stem cell function and gut homeostasis through the modulation of the GABA signalling pathway in Drosophila.Cell proliferation · 2023Article
- Measuring metabolic rate in single flies during sleep and waking states via indirect calorimetry.Journal of neuroscience methods · 2022Article
- Chronic circadian disruption on a high-fat diet impairs glucose tolerance.Metabolism: clinical and experimental · 2022Article
- Effects of early life stress during stress hyporesponsive period (SHRP) on anxiety and curiosity in adolescent rats.Experimental brain research · 2022Article
- Neurobehavioral alterations in a mouse model of chronic partial sleep deprivation.Metabolic brain disease · 2021Article
- Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance.Frontiers in physiology · 2021Article
- Chronic oral administration ofLaboratory animal research · 2019Article
- The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure.Frontiers in behavioral neuroscience · 2018Review
- Article
- Resting energy expenditure in OSAS: the impact of a single CPAP application.Sleep & breathing = Schlaf & Atmung · 2016Article
- Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During Chronic REM Sleep Deprivation of Rats.PloS one · 2016Article
- Behavioral sleep-wake homeostasis and EEG delta power are decoupled by chronic sleep restriction in the rat.Sleep · 2015Article
- Psychomotor vigilance task performance during and following chronic sleep restriction in rats.Sleep · 2015Article
- Sleep deprivation does not affect neuronal susceptibility to mild traumatic brain injury in the rat.Nature and science of sleep · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesShort sleep is a putative risk factor for obesity. However, prolonged total sleep deprivation (TSD) leads to negative energy balance and weight loss in rodents, whereas sleep-restricted humans tend to gain weight. We hypothesized that energy expenditure (VO2) is influenced by the rate of accumulation of sleep deficit in rats. DESIGN AND
interventionSix Sprague-Dawley rats underwent chronic sleep-restriction (CSR, 6-h sleep opportunity at ZT0-6 for 10 days) and stimulus-control protocols (CON, 12-h sleep opportunity for 10 days, matched number of stimuli) in a balanced cross-over design. Four additional rats underwent TSD (4 days). Sleep was manipulated using a motor-driven walking wheel. MEASUREMENTS AND
resultsElectroencephalography, electromyography, and body temperature were measured by telemetry, and VO2, by respirometry. Total sleep deficits of 55.1 +/- 6.4 hours, 31.8 +/- 6.8 hours, and 38.2 +/- 2.3 hours accumulated over the CSR, CON, and TSD protocols, respectively. Responses to TSD confirmed previous reports of elevated VO2 and body temperature. These responses were attenuated in CSR, despite a greater cumulative sleep deficit. Rate of rise of VO2 was strongly correlated with rate of accumulation of sleep deficit, above a threshold deficit of 3.6 h x day(-1).
conclusionThe change in VO2 is affected by rate of accumulation of sleep deficit and not the total sleep loss accrued. Negative energy balance, observed during TSD, is strongly attenuated when brief daily sleep opportunities are available to rats (CSR), despite greater accumulated sleep deficit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.