Trial reportSleep2010
Enhancing slow wave sleep with sodium oxybate reduces the behavioral and physiological impact of sleep loss.
Trial report in Sleep, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid.Annals of neurology · 2020Trial
- Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in male healthy volunteers may reflect biomimetic sleep enhancement: a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Trial
- The critical role of sleep spindles in hippocampal-dependent memory: a pharmacology study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory.Sleep · 2012Trial
- Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer's mouse model.iScience · 2025Article
- The association between salivary IL-6 and poor sleep quality assessed using Apple watches in stressed workers in Japan.Scientific reports · 2024Article
- From macro to micro: slow-wave sleep and its pivotal health implications.Frontiers in sleep · 2024Review
- Sleep Dysfunction in Huntington's Disease: Impacts of Current Medications and Prospects for Treatment.Journal of Huntington's disease · 2023Review
- Research Evidence of the Role of the Glymphatic System and Its Potential Pharmacological Modulation in Neurodegenerative Diseases.Journal of clinical medicine · 2022Review
- Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022Article
- Multimodal sleep, an innovation for treating chronic insomnia: case report and literature review.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Review
- The sleep and circadian problems of Huntington's disease: when, why and their importance.Journal of neurology · 2021Article
- The Treatment of Sleep Dysfunction in Neurodegenerative Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Slow-wave sleep is associated with incident hypertension in patients with obstructive sleep apnea: a cross-sectional study.The Journal of international medical research · 2020Article
- Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer's Disease and the Blood-Brain Barrier.International journal of molecular sciences · 2020Review
- High-Resolution Spectral Sleep Analysis Reveals a Novel Association Between Slow Oscillations and Memory Retention in Elderly Adults.Frontiers in aging neuroscience · 2020Article
- Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes.The Yale journal of biology and medicine · 2019Review
- Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy.Sleep medicine reviews · 2019Review
- Slow wave activity and executive dysfunction in children with sleep disordered breathing.Sleep & breathing = Schlaf & Atmung · 2018Article
- Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics.Annals of neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo investigate whether enhancement of slow wave sleep (SWS) with sodium oxybate reduces the impact of sleep deprivation.
designDouble-blind, parallel group, placebo-controlled design
settingSleep research laboratory
participantsFifty-eight healthy adults (28 placebo, 30 sodium oxybate), ages 18-50 years.
interventionsA 5-day protocol included 2 screening/baseline nights and days, 2 sleep deprivation nights, each followed by a 3-h daytime (08:00-11:00) sleep opportunity and a recovery night. Sodium oxybate or placebo was administered prior to each daytime sleep period. Multiple sleep latency test (MSLT), psychomotor vigilance test (PVT), Karolinska Sleepiness Scale (KSS), and Profile of Mood States were administered during waking hours. MEASUREMENTS AND
resultsDuring daytime sleep, the sodium oxybate group had more SWS, more EEG spectral power in the 1-9 Hz range, and less REM. Mean MSLT latency was longer for the sodium oxybate group on the night following the first daytime sleep period and on the day following the second day sleep period. Median PVT reaction time was faster in the sodium oxybate group following the second day sleep period. The change from baseline in SWS was positively correlated with the change in MSLT and KSS. During recovery sleep the sodium oxybate group had less TST, SWS, REM, and slow wave activity (SWA) than the placebo group.
conclusionsPharmacological enhancement of SWS with sodium oxybate resulted in a reduced response to sleep loss on measures of alertness and attention. In addition, SWS enhancement during sleep restriction appears to result in a reduced homeostatic response to sleep loss.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.