ArticleWorld journal of gastroenterology2010
Recent standardization of treatment strategy for pancreatic neuroendocrine tumors.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- [Endocrine journal · 2026Review
- Prognostic and Predictive Significance of Selected Gene Mutations in Pancreatic and Intestinal Neuroendocrine Tumors.International journal of molecular sciences · 2026Review
- Middle-segment preserving pancreatectomy: a literature review and case report.Langenbeck's archives of surgery · 2024Review
- Endoscopic ultrasonography-based intratumoral and peritumoral machine learning radiomics analyses for distinguishing insulinomas from non-functional pancreatic neuroendocrine tumors.Frontiers in endocrinology · 2024Article
- Article
- Identifying target ion channel-related genes to construct a diagnosis model for insulinoma.Frontiers in genetics · 2023Article
- Article
- Distinctive detection of insulinoma using [Scientific reports · 2021Article
- A case of insulinoma diagnosed postpartum with hypoglycemic symptoms that were masked during pregnancy.Clinical case reports · 2021Article
- Usefulness of selective arterial calcium injection tests for functional pancreatic neuroendocrine tumors.Scientific reports · 2021Article
- Multiple endocrine neoplasia 1: a broad overview.Therapeutic advances in chronic disease · 2021Review
- Pancreatic Neuroendocrine Tumor presenting as a diffuse pancreatic enlargement, case report and review of literature.Journal of radiology case reports · 2021Review
- Low-dose Selective Arterial Calcium Stimulation Test for Localizing Insulinoma: A Single-center Experience of Five Consecutive Cases.Internal medicine (Tokyo, Japan) · 2020Article
- Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies.World journal of gastroenterology · 2019Review
- Insulinoma with a History of Epilepsy: Still a Possible Misleading Factor in the Early Diagnosis of Insulinoma.Internal medicine (Tokyo, Japan) · 2017Article
- Natural History of MEN1 GEP-NET: Single-Center Experience After a Long Follow-Up.World journal of surgery · 2017Article
- Challenging Differential Diagnosis of Hypergastremia and Hyperglucagonemia with Chronic Renal Failure: Report of a Case with Multiple Endocrine Neoplasia Type 1.Internal medicine (Tokyo, Japan) · 2017Article
- Management of gastric and duodenal neuroendocrine tumors.World journal of gastroenterology · 2016Review
- Role of (68)Ga-DOTATATE PET/CT in patients with multiple endocrine neoplasia type 1 (MEN1).Endocrine · 2016Observational
- Endocrine neoplasms in familial syndromes of hyperparathyroidism.Endocrine-related cancer · 2016Review
Corrections and comments
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1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in localization techniques, such as the selective arterial secretagogue injection test (SASI test) and somatostatin receptor scintigraphy have promoted curative resection surgery for patients with pancreatic neuroendocrine tumors (PNET). For patients with sporadic functioning PNET, curative resection surgery has been established by localization with the SASI test using secretin or calcium. For curative resection of functioning PNET associated with multiple endocrine neoplasia type 1 (MEN 1) which are usually multiple and sometimes numerous, resection surgery of the pancreas and/or the duodenum has to be performed based on localization by the SASI test. As resection surgery of PNET has increased, several important pathological features of PNET have been revealed. For example, in patients with Zollinger-Ellison syndrome (ZES), duodenal gastrinoma has been detected more frequently than pancreatic gastrinoma, and in patients with MEN 1 and ZES, gastrinomas have been located mostly in the duodenum, and pancreatic gastrinoma has been found to co-exist in 13% of patients. Nonfunctioning PNET in patients with MEN 1 becomes metastatic to the liver when it is more than 1 cm in diameter and should be resected after careful observation. The most important prognostic factor in patients with PNET is the development of hepatic metastases. The treatment strategy for hepatic metastases of PNET has not been established and aggressive resection with chemotherapy and trans-arterial chemoembolization have been performed with significant benefit. The usefulness of octreotide treatment and other molecular targeting agents are currently being assessed.
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