ArticleMacromolecular bioscience2010
Multifunctional hybrid three-dimensionally woven scaffolds for cartilage tissue engineering.
Article in Macromolecular bioscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed.
- Evaluation of Osteogenic Potential for Rat Adipose-Derived Stem Cells under Xeno-Free Environment.International journal of molecular sciences · 2023Article
- Electrospun-Reinforced Suturable Biodegradable Artificial Cornea.ACS applied bio materials · 2022Article
- Functional tissue engineering of articular cartilage for biological joint resurfacing-The 2021 Elizabeth Winston Lanier Kappa Delta Award.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- The Rheology and Printability of Cartilage Matrix-Only Biomaterials.Biomolecules · 2022Article
- Implication of Mesenchymal Stem Cells and Their Derivates for Osteochondral Regeneration.International journal of molecular sciences · 2022Review
- Biological resurfacing in a canine model of hip osteoarthritis.Science advances · 2021Article
- Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids.Clinical and translational medicine · 2021Article
- Chondrogenic, hypertrophic, and osteochondral differentiation of human mesenchymal stem cells on three-dimensionally woven scaffolds.Journal of tissue engineering and regenerative medicine · 2019Article
- Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments.Materials (Basel, Switzerland) · 2018Review
- Comparison of Fixation Techniques of 3D-Woven Poly(ϵ-Caprolactone) Scaffolds for Cartilage Repair in a Weightbearing Porcine Large Animal Model.Cartilage · 2018Article
- Composite Cellularized Structures Created from an Interpenetrating Polymer Network Hydrogel Reinforced by a 3D Woven Scaffold.Macromolecular bioscience · 2018Article
- Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold.Scientific reports · 2018Article
- Functionality of decellularized matrix in cartilage regeneration: A comparison of tissue versus cell sources.Acta biomaterialia · 2018Review
- The impact of functional groups of poly(ethylene glycol) macromers on the physical properties of photo-polymerized hydrogels and the local inflammatory response in the host.Acta biomaterialia · 2018Article
- Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies.Engineering (Beijing, China) · 2017Article
- Silk fibroin/cartilage extracellular matrix scaffolds with sequential delivery of TGF-β3 for chondrogenic differentiation of adipose-derived stem cells.International journal of nanomedicine · 2017Article
- The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering.Frontiers in bioengineering and biotechnology · 2017Review
- Anatomically shaped tissue-engineered cartilage with tunable and inducible anticytokine delivery for biological joint resurfacing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Dedifferentiated Human Articular Chondrocytes Redifferentiate to a Cartilage-Like Tissue Phenotype in a Poly(ε-Caprolactone)/Self-Assembling Peptide Composite Scaffold.Materials (Basel, Switzerland) · 2016Article
- Fabrication of anatomically-shaped cartilage constructs using decellularized cartilage-derived matrix scaffolds.Biomaterials · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The successful replacement of large-scale cartilage defects or osteoarthritic lesions using tissue-engineering approaches will likely require composite biomaterial scaffolds that have biomimetic mechanical properties and can provide cell-instructive cues to control the growth and differentiation of embedded stem or progenitor cells. This study describes a novel method of constructing multifunctional scaffolds for cartilage tissue engineering that can provide both mechanical support and biological stimulation to seeded progenitor cells. 3-D woven PCL scaffolds were infiltrated with a slurry of homogenized CDM of porcine origin, seeded with human ASCs, and cultured for up to 42 d under standard growth conditions. These constructs were compared to scaffolds derived solely from CDM as well as 3-D woven PCL fabric without CDM. While all scaffolds promoted a chondrogenic phenotype of the ASCs, CDM scaffolds showed low compressive and shear moduli and contracted significantly during culture. Fiber-reinforced CDM scaffolds and 3-D woven PCL scaffolds maintained their mechanical properties throughout the culture period, while supporting the accumulation of a cartilaginous extracellular matrix. These findings show that fiber-reinforced hybrid scaffolds can be produced with biomimetic mechanical properties as well as the ability to promote ASC differentiation and chondrogenesis in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.