Evidence map›Paper›PMID 20857237›Full record

ReviewCurrent hypertension reports2010

Vascular endothelial function and hypertension: insights and directions.

Kodlipet Dharmashankar, Michael E Widlansky

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current hypertension reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effects of excess sodium consumption on arterial function in C57BL/6 mice.American journal of physiology. Heart and circulatory physiology · 2024
    Pooled it
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  4. Endocan as a marker of endothelial dysfunction in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
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  8. The Influence of Fasting and Energy Restricting Diets on Blood Pressure in Humans: A Systematic Review and Meta-Analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020
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  13. Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016
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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kodlipet DharmashankarMedical College of Wisconsin, 9200 West Wisconsin Avenue, FEC Suite E5100, Milwaukee, WI 53226, USA.
Michael E Widlansky

Funding

HYPERTENSION TRAINING GRANTT32HL007792 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HARDER, DAVID RAE · 1994 to 2013
$3.7M
Importance of Mitochondria in the Endothelial Dysfunction of Type 2 DiabetesK23HL089326 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2009 to 2013
$680k
NHLBI NIH HHS HL007792-15NHLBI NIH HHS K23 HL089326NHLBI NIH HHS K23HL089326NHLBI NIH HHS T32 HL007792
6 · The paper itself

Abstract

Hypertension contributes significantly to worldwide cardiovascular morbidity and mortality. Hypertension appears to have a complex association with endothelial dysfunction, a phenotypical alteration of the vascular endothelium that precedes the development of adverse cardiovascular events and portends future cardiovascular risk. This review concentrates on recent findings with respect to the mechanisms of hypertension-associated endothelial dysfunction, the interrelationship between these two entities, and the relationship of the efficacy of antihypertensive therapies to improvements in vascular homeostasis beyond blood pressure reduction. Current evidence suggests that hypertension and endothelial dysfunction are integrally related with respect to pathophysiologic mechanisms. Future studies will need to identify the key connections between hypertension and endothelial dysfunction to allow novel interventions to be designed and promulgated.

Indexed as

Endothelium, VascularHypertensionAnimalsAntihypertensive AgentsBlood PressureClinical Trials as TopicDiet, Sodium-RestrictedEndothelium-Dependent Relaxing FactorsHumansHypolipidemic AgentsMiceModels, AnimalOxidative StressRatsReactive Oxygen SpeciesRisk FactorsAntihypertensive AgentsEndothelium-Dependent Relaxing FactorsHypolipidemic AgentsReactive Oxygen Species

Identifiers

PMID20857237
PMCPMC2982873

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.