ArticleMolecular biology reports2011
Accumulation of β-catenin by lithium chloride in porcine myoblast cultures accelerates cell differentiation.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Low-dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice.The Journal of physiology · 2026Article
- GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy.Nature communications · 2024Article
- Obstetric Outcomes in Women on Lithium: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- LncRNA XLOC_015548 affects the proliferation and differentiation of myoblasts via the MAPK signaling pathway.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation.Current neuropharmacology · 2023Review
- Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs.Molecular and cellular biochemistry · 2022Article
- Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related.International journal of molecular sciences · 2021Article
- Article
- Shh-Mediated Increase in β-Catenin Levels Maintains Cerebellar Granule Neuron Progenitors in Proliferation.Cerebellum (London, England) · 2020Article
- Canagliflozin inhibits growth of hepatocellular carcinoma via blocking glucose-influx-induced β-catenin activation.Cell death & disease · 2019Article
- Ciliotherapy Treatments to Enhance Biochemically- and Biophysically-Induced Mesenchymal Stem Cell Osteogenesis: A Comparison Study.Cellular and molecular bioengineering · 2019Article
- mTORC1 Prevents Epithelial Damage During Inflammation and Inhibits Colitis-Associated Colorectal Cancer Development.Translational oncology · 2019Article
- Rbm46 regulates mouse embryonic stem cell differentiation by targeting β-Catenin mRNA for degradation.PloS one · 2017Article
- A role for the Wnt3a/β-catenin signaling pathway in the myogenic program of C2C12 cells.In vitro cellular & developmental biology. Animal · 2016Article
- Article
- The proliferation and differentiation characteristics of co-cultured porcine preadipocytes and muscle satellite cells in vitro.Molecular biology reports · 2013Article
- Cloning and characterization of β-catenin gene in early embryonic developmental stage of Artemia sinica.Molecular biology reports · 2012Article
- Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.Developmental biology · 2012Article
- Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells.Journal of molecular signaling · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Wnt/β-catenin signaling pathway regulates cell proliferation and differentiation to determine cell fate during embryogenesis. Lithium chloride (LiCl) is known to activate canonical Wnt signaling by inhibiting glycogen synthetase kinase-3β and consequently stabilizing free cytosolic β-catenin. To understand the role of the Wnt/β-catenin pathway in the regulation of porcine myoblast differentiation, we studied the effects of LiCl on cultured porcine myoblasts and β-catenin expression. A supplementation of 25 mM LiCl induced myoblast differentiation into myotubes over 3 days of culture. By semi-quantitative RT-PCR analyses, levels of mRNA encoding MyoD, Myogenin, Myf5 and several Wnt-responsive genes in the cultured myoblast cells were significantly increased after LiCl treatment. Using Western blotting and immunofluorescence analysis, we found that the protein levels of β-catenin were consistently increased by LiCl. Meanwhile, phosphorylated GSK-3β at Ser9 levels were also increased as an indicator of GSK-3β inactivation. Additionally, the nuclear staining of endogenous β-catenin was also significantly increased in porcine myoblasts 48 h after LiCl treatment. These results provided additional evidence that Wnt/β-catenin is a significant pathway that regulates myogenic differentiation. An enhanced level of β-catenin plays a positive role in porcine myoblast differentiation.
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Registered trials
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