ArticleMolecular biology reports2011
Pigment epithelium-derived factor plays an inhibitory role in proliferation and migration of HaCaT cells.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Skin Wound Healing and Anti-Wrinkle-Promoting In Vitro Biological Activities ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Chemical Composition ofPlants (Basel, Switzerland) · 2022Article
- A Role for Low-Density Lipoprotein Receptor-Related Protein 6 in Blood Vessel Regression in Wound Healing.Advances in wound care · 2020Article
- Gentisic Acid Stimulates Keratinocyte Proliferation through ERK1/2 Phosphorylation.International journal of medical sciences · 2020Article
- Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis.Scientific reports · 2018Article
- Production and function of pigment epithelium-derived factor in isolated skin keratinocytes.Experimental dermatology · 2014Article
- Downregulation of CD9 in keratinocyte contributes to cell migration via upregulation of matrix metalloproteinase-9.PloS one · 2013Article
- Interleukin-6 up-regulates the expression of interleukin-15 is associated with MAPKs and PI3-K signaling pathways in the human keratinocyte cell line, HaCaT.Molecular biology reports · 2012Article
- The effect of secretory factors of adipose-derived stem cells on human keratinocytes.International journal of molecular sciences · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The normal vasculature is maintained by a balance between angiogenic factors and anti-angiogenic factors. Recent studies have shown that pigment epithelium-derived factor (PEDF) can induce differentiation and inhibit angiogenesis of tumors. This study was designed to investigate the expression of PEDF and its roles in proliferation, adhesion and migration of HaCaT cells, a human keratinocyte cell line. Our results have shown that PEDF is expressed in HaCaT cells at both mRNA and protein levels determined by RT-PCR and Western blot, separately. PEDF signal mainly localizes in the cytoplasm of HaCaT cell, as determined by immunofluorescence. Furthermore, expression of PEDF is decreased by 50 ng/ml of VEGF(165). Proliferation and migration of HaCaT cells are decreased by PEDF, while adhesion of HaCaT cells is upregulated approximately by 29%. PEDF also induce the S phase accumulation of HaCaT cells. In addition, phosphorylation of ERK1/2, not JNK and p38, is decreased by PEDF. These results indicate that PEDF may play an inhibitory role on growth and migration of HaCaT cells through dephosphorylation of ERK1/2.
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Registered trials
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