ReviewEuropean journal of applied physiology2011
Gravity, the hydrostatic indifference concept and the cardiovascular system.
Review in European journal of applied physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The impact of biological sex and stroke volume constituents on heterogeneity in theExperimental physiology · 2026Article
- Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest.Experimental physiology · 2026Article
- Cardiovascular Exercise Physiology Under Hypoxia, Microgravity, and Heat Stress: A Review with Public Health Implications.International journal of environmental research and public health · 2026Review
- Hypogravity simulation using the Variable Gravity Suspension System: A technical report.Experimental physiology · 2026Article
- Does exercising bilaterally require measuring bilaterally? Bilateral versus unilateral tourniquet cuff inflation during measurement of arterial occlusion pressure: considerations for blood flow restriction exercise.Frontiers in physiology · 2026Article
- Fluid Volume Estimation by Bioimpedance: Methodological Caveats and Clinical Interpretation.American journal of nephrology · 2025Review
- "Chronic Cervical Midline Contusion in Rats Disrupts Aerobic, Muscular, and Cardiovascular Function".bioRxiv : the preprint server for biology · 2025Article
- Acute Metabolic Effects in Brazilian A-29 Fighter Pilots by NMR-Based Metabolomics.Journal of proteome research · 2025Article
- The effect of body position on cardiovascular, skeletal muscle and ventilatory responses to submaximal cycling.Experimental physiology · 2025Article
- Space Travel: The Radiation and Microgravity Effects on the Cardiovascular System.International journal of molecular sciences · 2024Review
- Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight.Nature reviews. Cardiology · 2024Review
- A Survey on Blood Pressure Measurement Technologies: Addressing Potential Sources of Bias.Sensors (Basel, Switzerland) · 2024Review
- Acute and short-term fluctuations in gravity are associated with changes in circulatory plasma protein levels.NPJ microgravity · 2024Article
- The impact of body position on neurofluid dynamics: present insights and advancements in imaging.Frontiers in aging neuroscience · 2024Review
- Head Elevation, Cerebral Venous System, and Intracranial Pressure: Review and Hypothesis.Stroke (Hoboken, N.J.) · 2023Review
- Dynamic asymmetry in cerebrospinal fluid pressure: An indicator of regional differences in compliance.Surgical neurology international · 2023Article
- Topically Confined Enhancement of Cutaneous Microcirculation by Cold Plasma.Skin pharmacology and physiology · 2022Article
- An anthropogenic model of cardiovascular system adaptation to the Earth's gravity as the conceptual basis of pathological anthropology.Journal of physiological anthropology · 2021Review
- The Effect of Space Travel on Bone Metabolism: Considerations on Today's Major Challenges and Advances in Pharmacology.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gravity, like any acceleration, causes a hydrostatic pressure gradient in fluid-filled bodily compartments. At a force of 1G, this pressure gradient amounts to 10 kPa/m. Postural changes alter the distribution of hydrostatic pressure patterns according to the body's alignment to the acceleration field. At a certain location--referred to as hydrostatically indifferent--within any given fluid compartment, pressure remains constant during a given change of position relative to the acceleration force acting upon the body. At this specific location, there is probably little change in vessel volume, wall tension, and the balance of Starling forces after a positional manoeuvre. In terms of cardiac function, this is important because arterial and venous hydrostatic indifference locations determine postural cardiac preload and afterload changes. Baroreceptors pick up pressure signals that depend on their respective distance to hydrostatic indifference locations with any change of body position. Vascular shape, filling volume, and compliance, as well as temperature, nervous and endocrine factors, drugs, and time all influence hydrostatic indifference locations. This paper reviews the physiology of pressure gradients in the cardiovascular system that are operational in a gravitational/acceleration field, offers a broadened hydrostatic indifference concept, and discusses implications that are relevant in physiological and clinical terms.
Indexed as
Identifiers
20857139What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.