ArticleClinical research in cardiology : official journal of the German Cardiac Society2011
Heart rate variability and biomarkers of systemic inflammation in patients with stable coronary heart disease: findings from the Heart and Soul Study.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03121911 (Effects of Interval Physical Training on Inflammatory Markers, Cardiac Autonomic Modulation at Rest, Expiratory Flow Limitation and Respiratory Efficiency in Recent Myocardial Infarction), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Interval Physical Training on Inflammatory Markers, Cardiac Autonomic Modulation at Rest, Expiratory Flow Limitation and Respiratory Efficiency in Recent Myocardial Infarction
Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected individuals.Biomarkers in medicine · 2014Trial
- Predicting the Risk of Cardiovascular Diseases in the Elderly Based on Clinical Data and Heart Rate Variability Using Machine Learning.Journal of clinical medicine · 2026Article
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- Review
- Cholesterol, triglycerides, HDL, and nitric oxide as determinants of resting heart rate variability in non-hospitalized mild post-COVID individuals: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Heart rate variability: a multidimensional perspective from physiological marker to brain-heart axis disorders prediction.Frontiers in cardiovascular medicine · 2025Review
- Neuro-immune axis in atherosclerosis: mechanisms of regulation and therapeutic opportunities.Frontiers in immunology · 2025Review
- Waterpipe smoking is associated with presence and severity of coronary artery disease: a propensity score-matched study.BMC cardiovascular disorders · 2024Article
- Association of Sports Practice in Childhood and Adolescence with Cardiac Autonomic Modulation in Adulthood: A Retrospective Epidemiological Study.Sports medicine - open · 2024Article
- Association between Sleep Quality and Cardiac Autonomic Modulation in Adolescents: A Cross Sectional Study.Sleep science (Sao Paulo, Brazil) · 2023Article
- Association between heart rate and cardiovascular death in patients with coronary heart disease: A NHANES-based cohort study.Clinical cardiology · 2022Article
- Heart Rate Variability and Circulating Inflammatory Markers in Midlife.Brain, behavior, & immunity - health · 2021Article
- Heart Rate Variability and Long ChainNutrients · 2021Article
- Novel Insights Into the Interaction Between the Autonomic Nervous System and Inflammation on Coronary Physiology: A Quantitative Flow Ratio Study.Frontiers in cardiovascular medicine · 2021Article
- A SNP involved in alternative splicing ofAging · 2020Article
- Harsh parenting and youth systemic inflammation: Modulation by the autonomic nervous system.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2020Article
- Association Between Systemic Inflammation, Carotid Arteriosclerosis, and Autonomic Dysfunction.Translational stroke research · 2020Article
- Very Low Frequency Heart Rate Variability Predicts the Development of Post-Stroke Infections.Translational stroke research · 2019Observational
- Article
- Heart Rate Variability: A Potential Tool for Monitoring Immunomodulatory Effects of Parenteral Fish Oil Feeding in Patients With Sepsis.Nutrition and metabolic insights · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundChronic low-grade systemic inflammation is a key component in atherogenesis. Decreased heart rate variability (HRV), a strong predictor of cardiovascular events, has been associated with elevations in circulating levels of C-reactive protein (CRP), interleukin (IL)-6, and fibrinogen in apparently healthy individuals. We investigated whether decreased HRV is associated with inflammatory markers in patients with coronary heart disease (CHD).
methodsWe studied the relationship between HRV and CRP, IL-6, and fibrinogen in 862 outpatients with CHD. All participants provided fasting blood samples and underwent 24-h ambulatory monitoring to assess time-domain measures of HRV (MeanNN, SDNN, SDANN, and RMSSD). Regression analyses were adjusted for age, sex, ethnicity, body mass index, smoking, diabetes, beta blocker use, and cardiopulmonary history.
resultsMeanNN, SDNN, and SDANN were significantly and inversely associated with CRP and IL-6 levels in age-adjusted models and after adjustment for all covariates (p ≤ 0.02). MeanNN, SDNN, and SDANN were also inversely associated with fibrinogen levels in age-adjusted models (p < 0.03), but not significantly so in multivariable-adjusted models. Reduced vagal modulation of heart rate (RMSSD) was not significantly associated with any inflammatory measures.
conclusionsReduced cardiac autonomic control is associated with increased systemic inflammation in patients with stable CHD. This relationship was largely independent of important covariates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.