ArticleEuropean radiology2011
Analysing the response in R2* relaxation rate of intracranial tumours to hyperoxic and hypercapnic respiratory challenges: initial results.
Article in European radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Dependency of the blood oxygen level dependent-response to hyperoxic challenges on the order of gas administration in intracranial malignancies.Neuroradiology · 2019Trial
- Using R2* values to evaluate brain tumours on magnetic resonance imaging: preliminary results.European radiology · 2014Trial
- Lesion magnetic susceptibility response to hyperoxic challenge: A biomarker for malignant brain tumor microenvironment?Magnetic resonance imaging · 2018Article
- Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2015Article
- Quantitative MR Imaging of Brain Tissue and Brain Pathologies.Clinical neuroradiology · 2015Review
- In vivo quantification of cerebral r2*-response to graded hyperoxia at 3 tesla.Journal of clinical imaging science · 2015Article
- Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T.NMR in biomedicine · 2012Article
- Hemodynamic response imaging: a potential tool for the assessment of angiogenesis in brain tumors.PloS one · 2012Article
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Authors and funding
11 authors.
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Abstract
objectiveTo investigate the response in R2* relaxation rate of human intracranial tumours during hyperoxic and hypercapnic respiratory challenges.
methodsIn seven patients with different intracranial tumours, cerebral R2* changes during carbogen and CO(2)/air inhalation were monitored at 3 T using a dynamic multigradient-echo sequence of high temporal and spatial resolution. The R2* time series of each voxel was tested for significant change. Regions of interest were analysed with respect to response amplitude and velocity.
resultsThe tumours showed heterogeneous R2* responses with large interindividual variability. In the 'contrast-enhancing' area of five patients and in the 'non-tumoral' tissue most voxels showed a decrease in R2* for carbogen. For the 'contrast-enhancing' area of two patients hardly any responses were found. In areas of 'necrosis' and perifocal 'oedema' typically voxels with R2* increase and no response were found for both gases. For tissue responding to CO(2)/air, the R2* changes were of the same order of magnitude as those for carbogen. The response kinetic was generally attenuated in tumoral tissue.
conclusionThe spatially resolved determination of R2* changes reveals the individual heterogeneous response characteristic of intracranial human tumours during hyperoxic and hypercapnic respiratory challenges.
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