ArticlePloS one2010
Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Effect of dietary n-3 PUFA supplementation on the muscle transcriptome in older adults.Physiological reports · 2016Trial
- The crosstalk between mitochondrial quality control and metal-dependent cell death.Cell death & disease · 2024Review
- N-3 Polyunsaturated Fatty Acid Dehydrogenase Fat-1 Regulates Mitochondrial Energy Metabolism by Altering DNA Methylation in Isolated Cells of Transgenic Cattle.Frontiers in molecular biosciences · 2022Article
- A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice.Aging · 2021Article
- Article
- Differential Mechanism of ATP Production Occurs in Response to Succinylacetone in Colon Cancer Cells.Molecules (Basel, Switzerland) · 2019Article
- Article
- The influence of Shc proteins and high-fat diet on energy metabolism of mice.Cell biochemistry and function · 2017Article
- Diabetes-induced abnormalities of mitochondrial function in rat brain cortex: the effect of n-3 fatty acid diet.Molecular and cellular biochemistry · 2017Article
- Murine diet-induced obesity remodels cardiac and liver mitochondrial phospholipid acyl chains with differential effects on respiratory enzyme activity.The Journal of nutritional biochemistry · 2017Article
- Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction.Aging cell · 2016Article
- CytochromeNPJ aging and mechanisms of disease · 2016Article
- Dietary Fatty Acids and Temperature Modulate Mitochondrial Function and Longevity in Drosophila.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice.Biogerontology · 2015Review
- The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats.Experimental gerontology · 2014Article
- Dietary fat, fatty acid saturation and mitochondrial bioenergetics.Journal of bioenergetics and biomembranes · 2014Article
- The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction.Physiological research · 2014Article
- Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations.Life sciences · 2013Article
- Dietary fat modifies mitochondrial and plasma membrane apoptotic signaling in skeletal muscle of calorie-restricted mice.Age (Dordrecht, Netherlands) · 2013Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
The polyunsaturated nature of n-3 fatty acids makes them prone to oxidative damage. However, it is not clear if n-3 fatty acids are simply a passive site for oxidative attack or if they also modulate mitochondrial reactive oxygen species (ROS) production. The present study used fat-1 transgenic mice, that are capable of synthesizing n-3 fatty acids, to investigate the influence of increases in n-3 fatty acids and resultant decreases in the n-6:n-3 ratio on liver mitochondrial H(2)O(2) production and electron transport chain (ETC) activity. There was an increase in n-3 fatty acids and a decrease in the n-6:n-3 ratio in liver mitochondria from the fat-1 compared to control mice. This change was largely due to alterations in the fatty acid composition of phosphatidylcholine and phosphatidylethanolamine, with only a small percentage of fatty acids in cardiolipin being altered in the fat-1 animals. The lipid changes in the fat-1 mice were associated with a decrease (p<0.05) in the activity of ETC complex I and increases (p<0.05) in the activities of complexes III and IV. Mitochondrial H(2)O(2) production with either succinate or succinate/glutamate/malate substrates was also decreased (p<0.05) in the fat-1 mice. This change in H(2)O(2) production was due to a decrease in ROS production from ETC complex I in the fat-1 animals. These results indicate that the fatty acid changes in fat-1 liver mitochondria may at least partially oppose oxidative stress by limiting ROS production from ETC complex I.
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