ArticleInternational journal of nanomedicine2010
Nano rare-earth oxides induced size-dependent vacuolization: an independent pathway from autophagy.
Article in International journal of nanomedicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 47 citations in OpenAlex.
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- Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells.International journal of nanomedicine · 2017Article
- The effect of red-allotrope selenium nanoparticles on head and neck squamous cell viability and growth.International journal of nanomedicine · 2016Article
- Application of dental nanomaterials: potential toxicity to the central nervous system.International journal of nanomedicine · 2015Review
- Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells.International journal of nanomedicine · 2015Article
- Central nervous system toxicity of metallic nanoparticles.International journal of nanomedicine · 2015Review
- Article
- Effect of Silver Coating on Barium Titanium Oxide Nanoparticle Toxicity.Advanced materials research · 2013Article
- Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides.Nature materials · 2012Article
- Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity.Particle and fibre toxicology · 2012Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four rare earth oxides have been shown to induce autophagy. Interestingly, we often noticed plentiful vacuolization, which was not always involved in this autophagic process. In this study, we investigated three other rare-earth elements, including Yttrium (Y), Ytterbium (Yb), and Lanthanum (La). Autophagic effect could be induced by all of them but only Y(2)O(3) and Yb(2)O(3) could cause massive vacuolization. Y(2)O(3) and Yb(2)O(3) treated by sonication or centrifugation to reduce particle size were used to test vacuolization level in HeLa cell lines. The results showed that rare earth oxides-induced vacuolization is size-dependent and differs from autophagic pathway. To further clarify the characteristics of this autophagic process, we used MEF Atg-5 (autophagy associated gene 5) knockout cell line, and the result showed that the autophagic process induced by rare earth oxides is Atg-5-dependent and the observed vacuolization was independent from autophagy. Similar results could also be observed in our tests on 3-methyladenine(3-MA), a well-known autophagy inhibitor. In conclusion, for the first time, we clarified the relationship between massive vacuolization and autophagic process induced by rare earth oxides and pointed out the size effect of rare earth oxides on the formation of vacuoles, which give clues to further investigation on the mechanisms underlying their biological effects.
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