ArticleJournal of immunology (Baltimore, Md. : 1950)2010
PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Assessment of Arf6 Deletion in PLB-985 Differentiated in Neutrophil-Like Cells and in Mouse Neutrophils: Impact on Adhesion and Migration.Mediators of inflammation · 2020Article
- HMBPP Analog Prodrugs Bypass Energy-Dependent Uptake To Promote Efficient BTN3A1-Mediated Malignant Cell Lysis by Vγ9Vδ2 T Lymphocyte Effectors.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation.Frontiers in immunology · 2016Review
- AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation.Nature communications · 2015Article
- The multifaceted role of PIP2 in leukocyte biology.Cellular and molecular life sciences : CMLS · 2015Review
- Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- SHARPIN regulates uropod detachment in migrating lymphocytes.Cell reports · 2013Article
- The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation.Biochemical pharmacology · 2013Article
- Article
- Article
- An Emerging Role for PI5P in T Cell Biology.Frontiers in immunology · 2013Article
- Chemokines and the signaling modules regulating integrin affinity.Frontiers in immunology · 2012Article
- Contact-dependent T cell activation and T cell stopping require talin1.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis.The EMBO journal · 2011Article
- The insider's guide to leukocyte integrin signalling and function.Nature reviews. Immunology · 2011Review
- The tail of integrin activation.Trends in biochemical sciences · 2011Review
- Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
T cell activation requires the formation and maintenance of stable interactions between T cells and APCs. The formation of stable T cell-APC contacts depends on the activation of the integrin LFA-1 (CD11aCD18). Several positive regulators of LFA-1 activation downstream of proximal TCR signaling have been identified, including talin; however, negative regulators of LFA-1 activity remain largely unexplored. Extended isoform of phosphatidylinositol phosphate kinase type I γ (PIPKIγ90) is a member of the type I phosphatidylinositol phosphate kinase family that has been shown previously to modulate talin activation of integrins through production of phosphatidylinositol 4,5-bisphosphate and direct binding to talin. In this study, we show that PIPKIγ90 negatively regulates LFA-1-mediated adhesion and activation of T cells. Using CD4(+) T cells from PIPKIγ90-deficient mice, we show that CD4(+) T cells exhibit increased LFA-1-dependent adhesion to ICAM-1 and increased rates of T cell-APC conjugate formation with enhanced LFA-1 polarization at the synapse. In addition to increased adhesiveness, PIPKIγ90-deficient T cells exhibit increased proliferation both in vitro and in vivo and increased production of IFN-γ and IL-2. Together, these results demonstrate that PIPKIγ90 is a negative regulator of Ag-induced T cell adhesion and activation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.